克拉霉素联合顺尔宁治疗支原体感染致慢性咳嗽

Clarithromycin Combined Singulair Treatment of Mycoplasma Infection-induced Chronic Cough

目的探讨克拉霉素联合白三烯受体拮抗剂顺尔宁治疗支原体感染致慢性咳嗽的临床疗效。方法符合咳嗽超过4周,咽试纸荧光定量多聚酶链反应技术(FQ-PCR)检测DNA阳性条件,确诊支原体感染致慢性咳嗽的患儿132例随机分为观察组68例和对照组64例.对照组64例均给予克拉霉素3周;观察组加用顺尔宁4周治疗。结果观察组患者显效38例,有效27例,无效3例,总有效率95.58%;对照组患者显效例27例,有效24例,无效13例,总有效率79.69%,两组患者疗效差异有统计学意义(t<0.05)。结论克拉霉素联合顺尔宁治疗支原体感染致小儿慢性咳嗽疗效明显,临床无明显不良反应。值得临床推广。

【Objective】 To investigate the clinical efficacy of clarithromycin combined leukotriene receptor antagonist-Singulair to treat children＇s chronic cough.caused by Mycoplasma pneumoniae.【Methods】 In line with cough more than four weeks and pharynx strip（or Sputum） fluorescence quantitative polymerase chain reaction（FQ-PCR） detection of DNA-positive conditions,chronic cough caused by mycoplasma infection diagnosed in children 132 cases were randomly divided into two group of 68 patients and a control group of 64 patients.The control group 64 patients were given clarithromycin for 3 weeks;The observation group were treated with 3 weeks ＇clarithromycin and together with 4 weeks ＇Singulair..Comparing treatment efficacy between the two groups.【Results】 Significant effect observed in patients in 38 cases,effective in 27 cases,ineffect in 3 cases,the total efficacy 95.58%;significant effect of the control group patients were 27 cases,effective in 24 cases,ineffective in 13 cases,the total efficacy 79.69%.Efficacy of the two groups were statistically significant difference（P0.05）.【Conclusion】 Clarithromycin combined with Singulair to deal with children ＇schronic cough caused by MP is effective.no significant clinical adverse reactions was found..and is worthy of promotion.