高胆红素血症对新生儿脑血流动力学的影响

Hyperbilirubinemia of the newborn cerebral hemodynamics

目的探讨高胆红素血症对新生儿脑血流动力学的影响。方法 2010-2011年我院新生儿病房住院的足月高胆红素血症新生儿50例为观察组,根据入院时血胆红素分组,将观察组分为观察组A(血胆红素220-272mol/L),观察组B(血胆红素>272mol/L),对照组为30例正常新生儿。各组均在入院后2小时内做脑血流动力学检查。结果观察组与对照组、观察组B与观察组A比较,收缩期峰值流速(Vs)、舒张末期血流速度(Vd)、时间平均流速(Vm)增加,搏动指数(PI)和阻力指数(RI)降低,脑血流量(CBF)增加,脑组织呈过度灌注状态。结论高胆红素血症使新生儿脑血流加速,随着血胆红素进一步升高,脑血流动力学紊乱进一步加剧。

【Objective】 To study the neonatal hyperbilirubinemia the impact of cerebral hemodynamics.【Methods】 neonatal hospital ward 2010-2011 term hospital neonatal hyperbilirubinemia group 50 cases observed,according to admission blood guts red element points to the observation group divided into two groups A（serum bilirubin 220-272mol / L）,the observation group B（serum bilirubin 272mol / L）,the control group of 30 normal neonates.Each group were done within 2 hours after admission cerebral blood flow examination.【Results】 observed with the control group,observation and observation group A,group B compared to peak systolic velocity（Vs）,end diastolic velocity（Vd）,time average velocity（Vm） increased pulsatility index（PI） and resistance index（RI） decreased cerebral blood flow（CBF） increase in brain tissue showed a hyperperfusion state.【Conclusion】 hyperbilirubinemia in neonatal cerebral blood flow to accelerate,with further increase in serum bilirubin,hemodynamic disorders further.