摘要
目的测定糖尿病患者的血清白介素-1β水平,分析白介素-1β与体重指数,空腹胰岛素、血糖、胰岛素抵抗指数、甘油三脂、胆固醇的相关性。方法精确测量受试者身高、体重;计算体重指数(BMI),同步检测空腹血糖(FPG);胰岛素(FINS),计算胰岛素抵抗指数(IR)、胆固醇(CH)、甘油三脂(TG),IL-1β测定用酶联免疫吸附(ELLSA)法双孔平行测定。结果糖尿病组IL-1β水平与对照组比较,差异有统计学意义(P<0.05);无论是糖尿病组还是对照组,肥胖者的IL-1β水平与非肥胖者的IL-1β相比较,差异有统计学意义(P<0.05),同时,相关分析显示IL-1β与BMI、FINS、FPG、IR、TG、CH均有相关性。结论白介素-1β水平在2型糖尿病组与对照组间有统计学差异,提示白介素-1β可能是肥胖和2型糖尿病之间联系的主要因素。
【Objective】 To measure the levels of serum IL-1βin patients with diabetes mellitus（DM） and make a correlative index（BMI）,fasting insulin level,glucose,insulin,resistance,Index（IR）,triglyceride,and cholesterol.【Methods】 The patients＇ heights and body weights were precisely measure and BMI were calculated.Meanwhile,measured the fasting levels of serum glucose,insulin,triglyceride and cholesterol,insulin resistance indexes were calculated.IL-1β were measured by immunone photometry assay.【Results】 The serum levels of IL-1βin patients group were significant sadistically（p0.05）.The serum levels of IL-1βof obese subjects were significantly different from that of non-obese subjects both in patient group and control group（p0.05）.The correlative analysis shown that the serum levels of IL-1β were correlated with BMI、FINS、FPG、IR、TG、CH respectively.【Conclusion】 There is significant difference on the serum levels of IL-1βboth in patient group and control group,indicating that serum IL-1βmaybe the main factor linking obesity and type 2 diabetes mellitus.
出处
《中国医学工程》
2011年第7期60-61,64,共3页
China Medical Engineering
