普瑞巴林治疗带状疱疹后神经痛的临床观察

Effects of Pregabalin on Patients with Post Herpetic Neuralgia

目的探讨普瑞巴林治疗带状疱疹后遗神经痛的临床效果与安全性。方法将36例带状疱疹后遗神经痛患者随机分为治疗组和对照组,在常规药物治疗基础上,治疗组(18例)给予普瑞巴林组口服150～600mg/d,分2-3次;对照组(18例)给予加巴喷丁口服900～2400 mg/d,分3次口服。观察时间6周。分别于治疗前及治疗后2、4、7、14、21、28、35、42d,分别采用VAS进行疼痛评估,中国版SF-36进行生活质量评价,同时观察镇痛效果和不良反应发生率。结果治疗组较对照组相比疼痛明显减轻,镇痛效果和生活质量优于对照组,且不良反应少(P<0.01)。结论普瑞巴林可迅速降低带状疱疹后神经痛,改善病人的生活质量,并有较好的耐受性。

【Objective】 To investigate the therapeutic effect and safety of Pregabalin（PGB）on patients with post herpetic neuralgia（PHN）.【Methods】 A total of 36 patients with PHN were randomLy divided into control group and treatment group.The control group（n =18） was treated with Gabapentin（GBP）orally 900～2400 mg per day,three times a day;In addition to routing medicine therapy,the treatment group（n=18） were given with PGB 150～600 mg per day,twice or three times a day.And the course of study last for 6 Months.All the patients were quantified with visual analogue scale（VAS） for pain severity and Chinese version of Short Form-36（SF-36） for living quality before and 2,4,7,21,28,35,and 42 days after the study.And anesthetic effect and adverse reaction of both medicines were recorded simultaneously.【Results】 The therapeutic group significantly improved pain,quality of life,and showed lower adverse reaction compare with controlled group（P0.01）.【Conclusion】 PGB can rapidly alleviate post herpetic neuralgia pain,enhance patients＇ quality of life,and was easily accepted by PHN patients for its good tolerance.