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造血干细胞移植治疗1型糖尿病 被引量：4

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摘要 造血干细胞移植治疗自身免疫性疾病的由来自体或异基因造血干细胞移植治疗自身免疫性疾病的概念已提出数年[1-3]。其基本原理是通过对患者进行大剂量化学治疗（化疗）或结合全身放射治疗（放疗）进行预处理．以最大限度地清除体内自身反应性克隆．使患者达到过度的免疫抑制或免疫去除．然后回输经体外免疫净化处理或未处理的自体骨髓或外周造血干细胞．
作者 顾卫琼
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢病科
出处 《内科理论与实践》 2011年第4期275-278,共4页 Journal of Internal Medicine Concepts & Practice
关键词 造血干细胞移植 1型糖尿病 非清髓免疫抑制
分类号 R587.1 [医药卫生—内分泌] R457.7 [医药卫生—治疗学]
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参考文献20

  • 1Burr RK, Arnold R, Emmons R, et al. Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting [J]. Bone Marrow Transplant, 2003, 32 Suppl 1: 3-5.
  • 2Tapprich C, Fenk R, Schneider P, et al. Early recurrence of rheumatoid arthritis after nonmyeloablative allogeneie blood stem cell transplantation in a patient with multiple myeloma[J]. Bone Marrow Transplant, 2003, 32(6): 629- 631.
  • 3Tyndall A, Fassas A, Passweg J, et al. Autologous haematopoietic stem cell transplants for autoimmune dis- ease--feasibility and transplant-related mortality[J]. Bone Marrow Transplant, 1999, 24(7): 729-734.
  • 4McColl G, Kohsaka H, Szer J, et al. High-dose chemotherapy and syngeneic hemopoietic stem-cell trans- plantation for severe, seronegative rheumatoid arthritis[J]. Ann Inter Med, 1999, 131(7): 507-509.
  • 5Tyndall A, Passweg J, Gratwohl A. Haemopoietic stem cell transplantation in the treatment of severe autoim- mune diseases 2000 [J]. Ann Rheum Dis, 2001, 60(7): 702-707.
  • 6Moore J, Brooks P, Milliken S, et al. A pilot randomized trim comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refracto- ry rheumatoid arthritis [J]. Arthritis Rheum, 2002, 46(9): 2301-2309.
  • 7Nikolic B, Takeuchi Y, Leykin I, et al. Mixed hematopoi- etic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity [J]. Diabetes, 2004, 53(2): 376-383.
  • 8Traynor AE, Barr WG, Rosa RM, et al. Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients [J]. Arthritis Rheum, 2002, 46(11): 2917-2923.
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  • 10Chatenoud L. Progress towards the clinical use of CD3 monoclonal antibodies in the treatment of autoimmunity [J]. Curr Opin Organ Transplant, 2009, 14(4): 351-356.

二级参考文献20

  • 1Bottini N.Role of PTPN22 in type 1 diabetes and other autoimmune diseases,Seminars in Immunology.2006,18:207-213.
  • 2Knip M,Veijola R,Virtanen SM,et al.Environmental triggers and determinants of type Ⅰ diabetes.Diabetes,2005,54 (Suppl 2):S125-S136.
  • 3Burt RK,Arnold R,Emmons R,et al.Stem cell therapy for autoimmune disease:overview of concepts from the snowbird 2002 tolerance and tissue regeneration meeting.Bone Marrow Transplantat,2003,32:3-5.
  • 4Beard ME,Willis JA,Scott RS,et al.Is type 1 diabetes transmissible by bone marrow allograft? Diabetes Care.2002,25:799-800.
  • 5Voltarelli JC,Couri CE,Stracieri AB,et al.Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.JAMA,2007,297:1568-1576.
  • 6Skyler JS.Cellular therapy for type 1 diabetes:has the time come?JAMA,2007,297:1599-1600.
  • 7Tyndall A,Fassas A,Passweg J,et al.Autologous haematopoietic stem cell transplants for autoimmune disease-feasibility and transplantrelated mortality.Autoimmune disease and lymphoma working parties of theEuropean group for blood and marrow transplantation,the european league against rheumatism and the international stem cell project for autoimmune disease.Bone Marrow Transplant,1999,24:729-734.
  • 8Openshaw H,Nash RA,McSweeney PA.High-dose immunosuppression and hematopoietic stem cell transplantation in autoimmune disease:clinical review.Biol Blood Marrow Transplant,2002,8:233 -248.
  • 9Tyndall A,Passweg J,Gratwohl A.Haemopoietic stem cell transplantation in the treatment of severe autoimmune diseases 2000.Ann Rheum Dis,2001,60:702-707.
  • 10Couri CEB,Oliveira MCB,Stracieri ABPL,et al.C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.JAMA,2009,301:1573-1579.

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内科理论与实践
2011年 第4期

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