网孔型纳米羟基磷灰石/聚酰胺66复合生物活性材料治疗早期股骨头缺血坏死的实验研究

Nano-hydroxyapatile/polyamide 66 biocomposites(n-HA/PA66) for treating early avascular necrosis of femoral head

目的观察网孔型纳米羟基磷灰石/聚酰胺66(n-HA/PA66)支撑棒及其复合血管内皮细胞生长因子(VEGF)后治疗兔股骨头早期缺血性坏死的实验效果。方法将n-HA/PA66支撑棒及VEGF缓释微球植入兔早期股骨头缺血坏死模型,术后3、6、12周行影像学及组织切片观察。结果植入n-HA/PA66支撑棒的实验兔未发现股骨头塌陷的影像学征象且骨质修复良好,其组织学检查显示新生骨长入n-HA/PA66,VEGF的持续缓释能促进骨长入及血管重建。结论网孔型n-HA/PA66支撑棒能有效预防早期股骨头缺血坏死的股骨头塌陷,VEGF缓释微球能加快骨修复过程。

Objective To observe the effect of porous n-HA/PA66 rods and vascular endothelial growth factor（VEGF） for treatment of early stage avascular necrosis of femoral head in rabbits.Methods The n-HA/PA66 supporting stick and VEGF microcapsul were implanted into the rabbit models of vascular necrosis of femoral head.Results were evaluated by radiograph and histology at the end of 3rd,6th and 12th week after operation.Results In the group B and C,no collapse of femoral head was observed.The New bone formation and the repair of the femoral head were observed by radiograph.Under microscope,the cancellous bone grew into cage.VEGF microcapsul can boost the progress of bone formation and.Conclusion It shows that the n-HA/PA66 is effective in providing structural support the subchondral bone and prevent collapse.And the composite of VEGF is active in inducing new bone formation and vascular remodeling.