儿童再发性腹痛与幽门螺杆菌感染的关系

Study of correlation between recurrent abdominal pain in children and helicobacter pylori infection

目的探讨儿童再发性腹痛(RAP)与幽门螺杆菌(Hp)的关系。方法选择我院儿科门诊符合RAP诊断的患儿84例,以同期42例无再发性腹痛的门诊儿童作为对照。采用13C-尿素呼气试验检测Hp感染情况。观察Hp阳性者治疗后患儿的腹痛缓解率,并对两组临床资料进行分析。结果 RAP组与对照组的Hp感染阳性率分别为52.4%和33.3%,两组比较有显著差异(P<0.05)。RAP组44例Hp阳性患儿中39例接受抗Hp治疗,治疗后Hp阴性和阳性的腹痛缓解率分别为78.8%和33.3%。两组比较有显著差异(P<0.05)。结论 RAP与Hp感染有密切关系,可能为RAP的主要病因之一,根治Hp治疗可缓解RAP儿童的腹痛症状。

Objective To study the correlation between children with recurrent abdominal pain（RAP） and helicobacter pylori（Hp） infection.Methods 84 patients with recurrent abdominal pain were enrolled in the research.42 patients without recurrent abdominal pain during the same period were taken as the control group.13C-urea breath test was used to detect whether the patient got infected by helicobacter pylori and the remission rate of children with RAP when the bacteria was eradicated.Results The positive rate of helicobacter pylori infection of the RAP group and the control group was 52.4%,33.3%,respectively（P0.05）.39 cases of 44 Hp-positive children with RAP got therapy.The lysis rate of abdominal pain in Hp-negative group was 78.8% while the rate in Hp-positive group was 33.3% with significant difference between the two groups（P0.05）.Conclusion There is a closed relation between RAP and Hp infection.Hp infection may be the main cause of RAP.Helicobacter pylori eradication therapy can alleviate the symptoms of abdominal pain in children.