父母出生体重与巨大儿的相关性研究

Correlation of parents＇ birth weight and fetal macrosomia

了解父母亲出生体重与巨大儿发生的关系,探讨巨大儿发生的遗传倾向.采用病例对照研究的方法,将237例巨大儿和257例正常体重儿父母的出生体重及孕期情况等资料做回顾性分析.经多因素非条件logistic回归分析,随着母亲和父亲出生体重增加,巨大儿发生的风险分别为OR=1.707,95%CI：1.145～2.545;OR=1.979,95%CI：1.306～2.998,巨大儿发生的遗传度为74.48%.巨大儿是胎儿期的肥胖,属多基因遗传.母亲可能通过携带的肥胖基因和宫内的环境,父亲可能主要通过携带的肥胖基因影响巨大儿的发生.

To investigate relationship between birth-weight of parents and fetal macrosomia and its genetic susceptibility. A case-control study with 237 macrosomia and 257 normal birth-weight babies was conducted to retrospectively analyze their parents＇ birth weight and mothers＇ conditions during pregnancy. Multivariate non-conditional logistic regression analysis showed that risk of macrosomia increased with increase in maternal birth-weight （OR = 1. 707, 95% CI： 1. 145 - 2. 545） and paternal birth-weight （OR = 1.979, 95%CI：1.306 -2.998）. Macrosomia is fetal obesity and related to multi-gene susceptibility with heritability of 74.48%. Maternal effect on macrosomia may come from her obesity gene and intrauterine condition, while paternal effect mainly exhibits by his obesity gene carriage.