不稳定型心绞痛患者血清细胞炎性因子的变化及意义

The change and its significance of serum inflammatory cytokines in patients with unstable angina pectoris

目的探讨不稳定型心绞痛(UAP)患者血清中IL-2、IL-10、TNF-α及CRP水平变化及意义。方法选取UAP患者40例(UAP组),稳定型心绞痛(SAP)患者38例(SAP组),健康查体者24例(健康对照组)。测定各组血清IL-2、IL-10、TNF-α及CRP水平,并观察UAP患者3个月内不良心脏事件发生情况。结果 UAP组血清IL-2、TNF-α及CRP水平明显高于健康对照组和SAP组(P<0.05);而IL-10水平明显低于健康对照组和SAP组(P<0.05)。随访3个月,UAP患者中,有心脏事件患者(14例)血清IL-2、TNF-α及CRP水平明显高于无心脏事件患者(24例),IL-10水平明显低于无心脏事件患者(P<0.05)。结论血清细胞炎性因子IL-2、IL-10、TNF-α及CRP水平变化可能与冠状动脉不稳定型斑块的发展有关,可反映冠心痛患者临床病情,判断UAP患者近期预后。

Objective To study of the peripheral serum IL-2,IL-10,TNF-αand CRP in patients with unstable angina pectoris（UAP） in order to evaluate the role of inflammatory factors in the development of UAP.Methods Forty patients with UAP,38 patients with SAP and 24 healthy volunteers were enrolled in the study.Serum levels of IL-2,IL-10,TNF-αand CRP were detected.The incidents of major cardiac events in three months were observed.All patients were evaluated with coronary angiography.Results The levels of IL-2,TNF-αand CRP were elevated in patients with UAP compared with those in patients with SAP and control group（P 0.05）.The levels of IL-10 was decreased in patients with UAP compared with that in patients with SAP and controls（P 0.05）.After 3 months follow up,among patients with UAP,the levels of IL-2,TNF-αand CRP were significantly higher in cardiac event group than without cardiac events group（P 0.05）.The levels of IL-10 was significantly lower in cardiac event group than without cardiac events group（P 0.05）.Conclusion Serum levels of IL- 2,IL-10,TNF-αand CRP may have diagnostic value for forecasting the incidents of UAP,and could be a useful marker to evaluate the stabilization of the disease.They also could predict the prognosis of patients with unstable angina pectoris.