摘要
目的:观测芹菜素对大肠癌细胞株SW480体外侵袭、粘附和运动能力的影响。方法:人工重组基底膜技术观察药物对细胞侵袭、运动和粘附的影响。结果:芹菜素处理后SW480细胞的侵袭、运动及粘附能力下降,并呈时间和剂量依赖性。结论:芹菜素多个层面抑制SW480细胞的侵袭、运动和粘附。
Objective:To explore the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Methods: Matrigel basement membrane matrix was used to investigate the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Results: After treated by apigenin,the ability of invasion,metastasis and adhesion descended with dose and time dependent.Conclusion: Apigenin could inhibit the ability of invasion,metastasis and adhesion.It could inhibit many key points in the invasive and metastasis process.
出处
《现代肿瘤医学》
CAS
2011年第8期1522-1524,共3页
Journal of Modern Oncology
基金
广东省科技计划项目(编号:2008B030301231)
广东省中医药局科研课题(编号:2008164)
汕头市重点科技计划项目(编号:2011015)
关键词
芹菜素
结肠肿瘤
侵袭
粘附
apigenin
colon carcinoma
invasion
adhesion