芹菜素对人结肠癌细胞株SW480体外侵袭能力的抑制作用

Inhibitory effect of apigenin on the invasive ability of the colon cancer cell SW480 in vitro

目的:观测芹菜素对大肠癌细胞株SW480体外侵袭、粘附和运动能力的影响。方法:人工重组基底膜技术观察药物对细胞侵袭、运动和粘附的影响。结果:芹菜素处理后SW480细胞的侵袭、运动及粘附能力下降,并呈时间和剂量依赖性。结论:芹菜素多个层面抑制SW480细胞的侵袭、运动和粘附。

Objective：To explore the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Methods： Matrigel basement membrane matrix was used to investigate the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Results： After treated by apigenin,the ability of invasion,metastasis and adhesion descended with dose and time dependent.Conclusion： Apigenin could inhibit the ability of invasion,metastasis and adhesion.It could inhibit many key points in the invasive and metastasis process.