p120ctn和Kaiso在食管癌中的表达及意义

p120ctn and Kaiso expression in esophageal cancer and its significance

目的:探讨p120ctn和Kaiso在食管癌组织中的表达及其与临床病理特征的关系。方法:采用免疫组织化学(SP)方法检测77例鳞状细胞癌、23例腺癌以及20例正常食管黏膜组织中p120ctn蛋白和Kaiso蛋白的表达,并进行相关性分析。结果:与正常食管黏膜组织相比,在食管鳞癌和食管腺癌组织中,p120ctn膜表达减少直至消失,细胞浆内表达逐渐增强,Kaiso蛋白主要表达于食管癌细胞浆内。在食管癌组织中p120ctn蛋白和Kaiso蛋白的表达与淋巴结转移及癌组织浸润深度密切相关(P<0.05),而与性别、年龄、组织学类型、分化程度无明显相关性(P>0.05)。结论:p120ctn蛋白和Kaiso蛋白的表达与食管癌的淋巴结转移和浸润深度密切相关,提示食管癌的发生发展可能与p120ctn和Kaiso有关,p120ctn和Kaiso可能是食管癌新的标志物和治疗靶点。

Objective：To study clinical pathological significance of p120ctn and Kaiso expressions in esophageal carcinoma.Methods： SP immunohistochemical method was used to detect the expression of p120ctn and Kaiso in 77 cases of esophageal squamous cell carcinoma,23 cases of esophageal adenocarcinoma and 20 cases of normal esophageal epithelium.The relationship between the expressions of p120ctn and Kaiso protein and the pathological features in esophageal carcinoma was analyzed statistically.Results： Compared with normal esophageal epithelium,in esophageal squamous cell carcinoma and esophageal adenocarcinoma,the membrane expression of p120ctn decreased or disappeared,and membranous expression significantly increased.Kaiso mainly expressed in cytoplasm.Moreover,there was a significant difference in the membranous expression of p120ctn and Kaiso between lymph node metastasis and no lymph node metastasis（P0.05）,as well as between serosa invasion and no serosa invasion（P0.05）.And there was no obvious relationship among gender,age,pathological type and differentiation degree（P0.05）.Conclusion： The expression of p120ctn and Kaiso was correlated with the depth of esophageal tumor invasion and lymph node metastasis,which showed that the occurrence and development of esophageal carcinoma may be related with p120ctn and Kaiso.p120ctn and Kaiso may act as a new symbol and target in the treatment of esophageal carcinoma.