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70例B细胞慢性淋巴细胞白血病中ZAP-70、CD38的表达 被引量：1

Exppressions of ZAP-70 and CD38 in chronic B lymphocytic leukaemia and their clinical significance
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摘要 目的:探讨ZETA相关蛋白(ZAP-70)、CD38在慢性B淋巴细胞白血病(B-CLL)病人骨髓及外周血中的表达及两者相关性,并分析其临床意义。方法:采用流式细胞术检测70例B-CLL病人及12例正常人骨髓或外周血ZAP-70、CD38的表达水平。结果:在70例B-CLL病人中,15例ZAP-70阳性表达,40例CD38阳性表达;对照组ZAP-70、CD38均阴性表达。结论:ZAP-70、CD38在B-CLL中表达与预后相关,阳性提示预后不良。 Objective：To study the expressions of ZAP-70 and CD38 in chronic B lymphocytic leukaemia（B-CLL） and the correlation between them.Methods： Flow cytometry was utilized to analyze ZAP-70 and CD38 expressions in patients with B-CLL（n=70） and normal adults（n=12）.Results： Positive expression of ZAP-70 was found only in fifteen patients with B-CLL and CD38 in forty patients.Conclusion： ZAP-70 and CD38 expressions predict poor prognosis of chronic lymphocytic leukaemia.
作者 夏乐敏 王运律 翁香琴
机构地区 上海市中医医院血液科 上海瑞金医院血液学研究所
出处 《现代肿瘤医学》 CAS 2011年第8期1668-1670,共3页 Journal of Modern Oncology
基金 2010年上海市中医医院院级课题(编号:130401)
关键词 慢性淋巴细胞白血病 ZAP-70 CD38 预后 chronic lymphocytic leukemia ZAP-70 CD38 prognosis
分类号 R733.7 [医药卫生—肿瘤]
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参考文献7

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同被引文献12

  • 1徐卫,李建勇,吴雨洁,盛瑞兰,陆风翔.29例慢性淋巴细胞白血病Ki-67和Bcl-2的表达及临床意义[J].中国实验血液学杂志,2006,14(3):464-467. 被引量：7
  • 2徐卫,李建勇,吴雨洁,盛瑞兰,陆凤翔.儿童和成人急性淋巴细胞白血病中Ki-67和Bcl-2表达的临床意义[J].中国实验血液学杂志,2006,14(5):887-890. 被引量：6
  • 3Pisani T, Pantellini F, Centanni M. et al. Immunocytochemical ex- pression of Ki67 and laminin in Hurthle cell adenomas and carcino- mas. Anticancer Res, 2003 ;23(4) :3323 -3326.
  • 4Bryant RJ, Banks PM, OMalley DP. Ki67 staining pattern as a diag- nostic tool in the evaluation of lymphoproliferative disorders. Histopa- thology, 2006 ;48 (5) :505 - 515.
  • 5Lee J, Im YH, Lee SH, et al. Evaluation of ER and Ki-67 prolifera- tion index as prognostic factors for survival following neoadjuvantche- motherapy with doxorubicin/docetaxel for locally advanced breast cancer. Cancer Chemother Pharmacol, 2008 ; 61 (4) :569 - 577.
  • 6Jones RL,Saher J,A'Hern R, et al. The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat, 2009; 116 (1) :53 -68.
  • 7Kimura Y, Sato K, Iamura Y, et al. Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow in- volvement, splenomegaly, and a low Ki-67 index. Cancer Sci, 2011 ; 102(9) : 1734 - 1741.
  • 8Hardiman G. Development of a bioassay to monitor circulating plasma Ki-67. Leuk Res, 2010; 34(7) :848 -849.
  • 9Nicholas Chiorazzi,王昭.慢性淋巴细胞白血病新的预后标志的含义.第54届美国血液年会论文集.2013:43-51.
  • 10Broey JM, Kantarjian H, Estrov Z, et al. Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lympho- blastic leukemia. Leuk Res, 2010; 34(2):173-176.

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现代肿瘤医学
2011年 第8期

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