卵巢癌组织中胃泌素释放肽及其受体的表达

Expression of gastrin-releasing peptide and its receptor in ovarian cancer tissue

目的:探讨卵巢癌组织中胃泌素释放肽(GRP)和其受体(GRPR)的表达及意义。方法:应用免疫组化技术检测58例卵巢癌、49例良性卵巢上皮性肿瘤和37例因子宫脱垂行子宫切除术要求切除一侧或双侧正常卵巢的卵巢组织中GRP和GRPR蛋白的表达,分析GRP和GRPR蛋白表达与卵巢癌患者临床病理特征的关系以及二者在卵巢癌中表达的关联性。结果:良性卵巢上皮性肿瘤组织和正常卵巢组织中GRP和GRPR的阳性表达率分别为10.2%、6.1%和8.1%、5.4%,卵巢癌组织中分别为44.8%和87.9%,3组相比差异有统计学意义(χ2=24.289和98.289,P均<0.001)。卵巢癌组织分化越差,GRP蛋白表达越高(χ2=7.608,P=0.006);GRPR蛋白表达与卵巢癌的分化程度、临床分期、有无腹水形成有关(χ2=6.849,4.700和8.026,P均<0.05)。卵巢癌组织中GRP和GRPR的表达无关联性(rp=0.194,P=0.131)。结论:GRP和GRPR可能参与了卵巢癌的癌变和进展,GRPR还可能与肿瘤的侵袭转移有关。

Aim：To investigate the expression of gastrin-releasing peptide（GRP）and its receptor（GRPR）in tissue of ovarian cancer（OC）.Methods：A total of pathology specimens of 58 patients with OC,49 patients with benign ovarian tumor and 37 patients without tumor were recuited.Immunohistochemistry was used to evaluate the expression level of GRP and GRPR in ovarian tissues.Clinical parameter of age,familial history,grade,stage,type,ascite and lymphatic metastasis were integrated.Results：GRP and GRPR were all overexpression in OC（44.8% and 87.9%）than benign tumor（10.2% and 6.1%）and normal group（8.1% and 5.4%）（χ2=24.289 and 98.289,P0.001）.The expression of GRP and GRPR seemed related to poor differentiation（χ2=7.608 and 9.249,P=0.006 and 0.002）.GRPR seemed related to stage,differentiation and ascite（χ2=4.700,6.849,and 8.026,P0.05）.The expression of GRP and GRPR did not show a correlation（rp=0.194,P=0.131）in OC tissue.Conclusion：GRP and GRPR might participate in the cancergenesis and development of OC,and GRPR seems a possible index of grade malignancy and metastasis.