摘要
目的:探讨成人膜性乙肝病毒相关性肾炎(HBV-MN)与特发性膜性肾病(IMN)临床病理特征之间的异同。方法:回顾性分析HBV-MN(70例)与IMV(137例)患者的临床病理资料,分析比较2组的临床病理特征。结果:HBV-MN发病年龄小于IMN[(31.7±14.0)岁vs(47.1±13.0)岁;t=3.533,P<0.001];病理上HBV-MN伴发系膜增生较IMN更常见(98.6%vs69.3%;χ2=24.048,P<0.001),HBV-MN多为多种免疫复合物沉积,2组IgM、IgA、C3、C1q(χ2=18.175、21.990、16.448和50.846,P均<0.001)、FRA(P=0.007)在肾组织的沉积率差异均有统计学意义。结论:HBV-MN与IMN临床特征相似,病理改变存在一定差别,诊断需要临床与病理相结合综合分析。
Aim:To investigate the clinical and pathological differences between HBV-associated membranous nephropathy(HBV-MN)and idiopathic membranous nephropathy(IMN)in adults.Methods:Two hundred and seven patients with HBV-MN(n=70)or IMN(n=137)were enrolled in this study.The clinical and pathological results were compared between the two groups.Results:The mean age of the HBV-MN group was significantly younger than that of IMN group[(31.7±14.0)years vs(47.1±13.0)years;t=3.533,P0.001)].Mesangial proliferation was more commonly observed in HBV-MN group than that of IMN group(98.6% vs 69.3%;χ2=24.048,P0.001),and immunofluorescence discovery of HBV-MN group was various immune-complex deposition,and the deposition of the immune-complex,IgM,IgA,C3,C1q(χ2=18.175,21.990,16.448,and 50.846,P0.001),FRA(P=0.007)in the renal tissue between these two groups was statistically significant.Conclusion:Clinical features of HBV-MN are similar to those of IMN,but the two groups have their own characteristics in pathology,so the combination of clinical and pathological features is necessary to the diagnosis.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2011年第4期601-604,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
膜性乙肝病毒相关性肾炎
特发性膜性肾病
成人
临床特点
病理特点
HBV-associated membranous nephropathy
idiopathic membranous nephropathy
adult
clinical feature
pathological feature