重症及危重症甲型H1N1流感与hs-CRP、NAP及CPIs的相关性研究

The relationship between Severe Pandemic H1N1 influenza and NAP、hs-CRP、CPIS

目的探讨NAP、hs-CRP及CPIs三个指标在重症及危重症甲型H1N1流感中数值变化,评价它们在重症及危重症HINI患者病情和预后中的应用价值。方法检测100例危重甲型H1H1患者超敏C反应蛋白(hs-CRP),中性粒细胞碱性磷酸酶(NAP)及临床肺部感染评分(CPIs),并比较这些指标在死亡组和生存组的差异及变化情况。结果入院第1天死亡组hs-CRP,NAP,CPIs等指标均明显高于存活组,三项指标随着治疗的深入,呈逐渐减少,hs-CRP与CPIs存在显著的正相关(r=0.609,P<0.01)。结论联合检测CPIs和hs-CRP对于判断甲型H1N1流感危重症患者病情和预后有重要的意义。

Objective To evaluate the value of hs-CRP,NAPand CPIS of determination in the Prognosis of Severe P influenza A H1N1.Methods Detected C-reactive protein（hs-CRP）,neutrophil alkaline phosphatase（NAP） and the clinical pulmonary infection score（CPIs） in 100 cases of patients with severe influenza A H1N1,and comparative analysis differences of these indicators in the death group and survival group,after that Spearman Correlation Analysis Between NAP,hs-CRP and CPIs in treatment 1th day.result：The death group significantly higher than the survival group on1th day with hs-CRP,NAP,CPIs.The three indicators as the depth of treatment,was gradually reduced,hs-CRP and CPIs significant positive correlation（r=0.609,P0.01）.Conclusion Joint Detection of CPIs and hs-CRP could be used as influenza A H1N1 illness and the prognosis of critically ill patients the importance of monitoring indicators.Conclusion Detection of CPIs and hs-CRP is important significance instate of an illness and prognosis of severe influenza A H1N1.