COPD合并T2DM患者血清visfatin与CRP的关系

The Relationship between Serum Visfatin and CRP in COPD and Type 2 Diabetes

目的探讨COPD合并2型糖尿病(T2DM)患者血清内脂素(visfatin)与C反应蛋白(CRP)的关系;研究visfatin与CRP对机体糖脂代谢与炎症免疫的影响。方法用酶联免疫吸附法(ELISA)测定血清visfatin水平;速率散射免疫比浊法检测CRP;全自动生化仪测定生化指标。结果 COPD合并2型糖尿病组血清visfatin与CRP水平较正常对照组明显升高[(36.20±3.62)μg/L/(69.75±8.92)mg/Lvs(15.04±0.71)μg/L/(4.75±2.43)mg/L],有统计学差异(P<0.05)。结论 COPD合并2型糖尿病患者血清visfatin与CRP水平明显升高。

Objective This study aimed to investigate the relationship between serum visfatin and CRP levels of COPD and type 2 diabetes,and the influence on fat metabolism and inflammatory and immune of visfatin CRP.Method Serum visfatin levels were determined by enzyme-linked immunosorbent assay（ELISA）,CRP were determined by rate of scattering immunoturbidimetry,and biochemicals were determined by automatic biochemical analazer.Results Serum visfatin and CRP in COPD and type 2 diabetes group were significantly heigher than the control group[（36.20±3.62）μg/L/（69.75±8.92）mg/L vs（15.04±0.71）μg/L/（4.75±2.43）mg/L],there were statistical differences（P0.05）.Conclusions Serum visfatin and CRP was significantly in a high level in COPD and type 2 diabetes.