AECOPD患者甲状腺激素水平变化及临床意义

The alterations of serum hyroid hormone levels in patients of AECOPD

目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者甲状腺激素水平的变化,探讨其临床意义。方法采用化学发光法测定102例AECOPD患者血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)水平,并与84例健康体检者进行对照。结果 AECOPD血清TT3、TT4、FT3与对照组比较差异有统计学意义(P<0.01);好转组与死亡组AECOPD患者血清TT3、FT3比较差异有统计学意义(P<0.05或P<0.01);无呼吸衰竭组与Ⅰ型呼衰组、Ⅱ型呼衰组患者血清TT3、FT3比较差异有统计学意义(P<0.01)。结论血清甲状腺激素水平变化反映AECOPD患者病情严重程度,可用于AECOPD患者病情的评估。

Objective To explore clinical significance of serum levels of thyroid hormones in patients with AECOPD.Methods Methods Serum thyroid hormone include levels of Serum triiodothyronin（TT3）,tetraiodothyronin（TT4）,free triiodothyronin（FT3）,free tetraiodothyronin（FT4） and thyroid stimulating hormone（TSH） were measured by chemiluminescence immunoassay in 102 AECOPD patients and 84 healthy subjects as controls.Results Serum levels of TT3,FT3,TT4 in group AECOPD were significantly lower than those in control group（P0.01）.The serum TT3,FT3 levels were significantly lower in the fatal cases of AECOPD than those in survival cases（P0.01 or P0.05）.The serum TT3,FT3 levels were significantly lower in the cases of AECOPD with respiratory failure than the other cases of AECOPD（P0.01）.Conculsion Monitoring of serum levels of thyroid hormones maybe useful in predicting their severity and outcome for patients with AECOPD.