老年人HALRTI的诊治与预防的临床研究

The Clinical study of treatment for oropharyngeal decontamination combined with gastrointestinal excitomotor in the elderly patients with hospital acquired lower respiratory tract infection

目的探讨老年医院获得性下呼吸道感染(HALRTI)的诊治和预防的临床研究。方法选择高危老年HALRTI者123例随机分组为A组(干预组)和B组(对照组),用西吡氯铵漱口液联合莫沙比利治疗,观察患者的疗效及毒副作用情况。结果 A组和B组的HALRTI发生率分别为1.6%和14.5%(P<0.05);干预组入选时咽拭子培养阳性8例,阳性率16.0%(8/50),随着干预时间延长,咽拭子培养的细菌阳性率逐渐降低(P<0.05),B组则无显著差异(P>0.05);两组咽拭子培养阳性菌株数和定植菌量的检验结果,经统计学分析无显著差异(P>0.05)。结论高危老年HALRTI者用西吡氯铵含漱液联合莫沙必利治疗具有很好疗效,降低HALRTI发生率,毒副作用小、安全性好,值得临床推广使用。

Objective To evaluate the clinical efficacy of treatment for oropharyngeal decontamination combined with gastrointestinal excitomotor in the elderly patients with HALRTI.Methods 123cases of the patients with HALRTI were divided into intervention group and control group.They can observed the curative effect and side effects of patients by the treatment for cetylpyridinium chloride garglec combined with gastrointestinal excitomotor.Results Patients suffered from HALRTI were 1 case 1.6%（1/61） in intervention group and 9 cases 14.5%（9/62） in control group respectively,the difference between two groups has statistical significance（P0.05）.The phyarynx swabs culture were positive in 8 cases of intervention group,the positive rate is 16.0%（8/50）.As intervention time became longer,the positive rate decreased gradually（P0.05）.The number of positive strains of the pharynx swabs culture and permanent planting bacteria had no statistical significance in the two groups（P0.05）.Conclusions It can have worth widely applies that oropharyngeal decontamination combined with the gastrointestinal excitomotor were treated by the patients with HALRTI,which will have very good treatment、reduced the incidence of the HALRTI、small toxicity and side effects、good safety.