胸腔内注射不同剂量顺铂治疗肺癌恶性胸水的疗效观察

Clinical observation of different doses of cisplatin by intrapleural injection on treatment of malignant pleural effusion of lung cancer

目的观察胸腔内注射不同剂量顺铂治疗肺癌恶性胸水的临床疗效和不良反应。方法 58例肺癌恶性胸水患者随机分为高剂量组（30例）和低剂量组（28例）。高剂量组采用顺铂80~100 mg/m2胸腔内灌注,每周1次,低剂量组采用顺铂30~50 mg/m2胸腔内灌注,每周1次。两组用药2~4次。结果高剂量组治疗总有效率为86.7%,低剂量组治疗总有效率为71.4%,两组比较差异有统计学意义（P〈0.05）,两组均出现Ⅰ~Ⅱ度恶心呕吐和白细胞下降,但差异无显著性（P〉0.05）,无肝肾功能异常。结论胸腔内注射大剂量顺铂治疗肺癌恶性胸水的临床疗效优于小剂量顺铂,且不良反应可以耐受。

Objective To investigate the clinical curative effect of different doses of cisplatin by intrapleural injection on treatment of malignant pleural effusion of lung cancer.Methods 58 cases of malignant pleural effusion of lung cancer were randomly divided into high-dose group（30 cases） and low-dose group（28 cases）.High-dose group were treated with cisplatin 80~100 mg/m2 by infusion of the chest,1 per week,low-dose group were treated with cisplatin 30~50 mg/m2 by infusion of the chest,1 per week.The time of treatment was 2 to 4 in two groups.Results The total effective rate of high-dose group and low-dose group was 86.7% and 71.4%.There was a statistically significant difference（P0.05）.The symptoms ofⅠ~Ⅱnausea,vomiting and leucopenia appeared in both groups,but the difference was not significant（P0.05）,no liver and kidney dysfunction.Conclusion The clinical curative effect of High dose cisplatin on treatment of malignant pleural effusion of lung cancer was better than low dose group,and adverse reactions could be tolerated.