温胆片改善高血压病血管内皮功能障碍的超声研究

Improvement of Vascular Endothelial Function Measured by Ultrasonography in Essential Hypertension Phlegm Syndrome after Wendan Capsule Intervention

目的探讨温胆片对痰浊型原发性高血压病患者血管内皮功能障碍的调节作用。方法选择低危、中危组痰浊型原发性高血压患者43例,按随机数字表法分为治疗组23例,对照组20例。在氨氯地平有效控制血压基础上治疗组口服温胆片,对照组口服安慰剂。应用彩超检测治疗前和治疗6个月后患者颈动脉内膜-中膜厚度(IMT)、肱动脉充血性和含服硝酸甘油后肱动脉内径的变化。结果治疗后内皮依赖性舒张功能改善治疗组优于对照组(P<0.05),但硝酸甘油诱发的非内皮依赖性舒张功能2组相比无显著性差异(P>0.05)。痰浊型原发性高血压病患者肱动脉内皮依赖性舒张功能与颈动脉IMT呈负相关(r=-0.596,P<0.05)。结论痰浊型高血压病颈动脉IMT与肱动脉内皮依赖性舒张功能呈负相关,温胆片对肱动脉内皮依赖性舒张功能异常有较好的改善作用。

Objective To observed the effect of Wendan capsules on vascular endothelial function in patients with essential hypertension phlegm syndrome.Methods Forty-three low or medium risk patients with essential hypertension phlegm syndrome were randomly divided into two groups：Treatment group（n=23）and control group（n=20）.All the patients were treated with Amlodipine to control blood pressure,treatment group was given oral wendan capsule.Control group was given oral placebo,treatment group was given oral wendan capsule.Color Doppler ultrasound was used to examine the carotid artery intima-media thickness（IMT）,blood flow mediated endothelium-dependent brachial artery dilation（FMD） and brachial artery flow-mediated dilation（NID） after taking nitroglycerin before and after treatment for 6 months.Results After treatment,the FMD in Wendan capsule group was significantly improved compared with the control group（P0.05）,but FMD after taking nitroglycerin showed no significant difference between the two groups（P0.05）.EDD showed a significant negative correlation with IMT in patients with essential hypertension phlegm syndrome（r=-0.596,P0.05）.Conclusion FMD is negatively correlated with IMT,and Wendan capsules can improve FMD in patients with essential hypertension phlegm syndrome.