摘要
完整而确定的HIV-1整合酶结构在基于受体的抗AIDS药物设计中起着重要的作用。概述了HIV-1整合酶的结构和功能,并从片段结构、模建的全长聚集体以及同源体系3个方面综述了整合酶结构的研究进展。给出了各个代表性体系的应用价值。旨在对HIV-1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
The full length of determined HIV-1(Human immunodeficiency virus type 1) integrase plays key roles in the anti-AIDS drug design based on the structure of acceptor.The structure and function of HIV-1 integrase and the advances in three aspects,segment structures,full length of constructed multimer and homologic systems,were summarized.The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
出处
《湖北农业科学》
北大核心
2011年第15期3032-3037,共6页
Hubei Agricultural Sciences
基金
四川省教育厅基金项目(08ZB054)
四川省中医药管理局科技专项基金项目(201003)