214例窒息新生儿血清心肌酶测定及临床意义

Test of serum cardiac enzymes in 214 neonates with asphyxia and the clinical significance

目的:探讨血清心肌酶活性测定在新生儿窒息中的临床应用价值。方法:测定214例窒息新生儿生后24 h内血清天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)水平并进行分析。结果:窒息新生儿心肌酶谱活性增高,重度窒息组CK及CK-MB水平均明显高于轻度窒息组(P<0.05)。心肌损害总发生率为85.05%,轻度窒息组为83.52%,重度窒息组为92.11%,二者比较差异无统计学意义(P>0.05)。结论:新生儿窒息后可致心肌损害,CK-MB活性增高是新生儿窒息后心肌损害的早期诊断方法之一。

Objective：To explore the clinical application value of activity test of serum cardiac enzymes in neonatal asphyxia.Methods：The serum levels of aspartate amino transferase（AST）,creatine kinase（CK） and isoenzymes of creatine kinase（CK-MB） in 214 neonates with asphyxia were detected within 24 hours after birth.Results：The activity of cardiac enzymes in neonates with asphyxia increased,the serum levels of CK and CK-MB in severe asphyxia group were significantly higher than those in mild asphyxia group（P〈0.05）.The total incidence of myocardial injury was 85.05%,there was no significant difference between mild asphyxia group（83.52%） and severe asphyxia group（92.11%）（P〉0.05）.Conclusion：Neonatal asphyxia can induce myocardial injury,the increase of CK-MB activity is a early method to diagnose myocardial injury after asphyxia in neonates.