Reactive protein, plasminogen activator inhibitor type-1 （PAI-1） levels, PAI-1 promoter 4G/5G polymorphism and acute myocardial infarction

调查在 CRP 之间的关系的目的，(PAI-1 ) plasminogen 使活跃之物禁止者类型 1 铺平， PAI-1 基因倡导者 4G/5G 多型性和尖锐心肌的梗塞的类型(圣举起心肌的梗塞， STEMI 对非圣举起心肌的梗塞， NSTEMI ) 。有 AMI 的 176 个连续病人为学习， 60 有 STEMI 和 56 有的 NSTEMI 被包括的方法，和没有心血管、脑血管的疾病的 60 个成年人作为控制被选择。血样品在 AMI 的 6 h 以内从病人被获得，血浆 PAI-1， CRP，和基因多型性被测量。 PAI-1 和 CRP 的结果血浆层次在 AMI 组是更高的，在控制组比较了那些，并且 PAI-1 的血浆层次在有有 NSTEMI 的与那些相比的 STEMI 的病人是显著地更高的( 80.12ng/mL vs.73.01ng/ml ， P < 0.01 )，吗当 CRP 层次不在有 STEMI 和 NSTEMI 的病人之间是显著地不同的时( 3.87 敤楬敶敲?景？

Objective To investigate the relationship between CRP, plasminogen activator inhibitor type 1 （PAI-1） levels, PAI-1 gene promoter 4G/5G polymorphism and the type of acute myocardial infarction （ST elevation myocardial infarction, STEMI vs the non-ST elevation Myocardial infarction, NSTEMI）. Methods One hundred seventy-six consecutive patients with AMI were included for the study, of whom 60 had STEMI and 56 had NSTEMI, and 60 adults without cardiovascular and cerebrovascular disease were selected as controls. Blood samples were obtained from patients within 6 h of AMI and the plasma PAI-1, CRP, and the gene polymorphism were measured. Results Plasma levels of PAI- 1 and CRP were higher in AMI groups, compared those in the control group, and plasma levels of PAI-1 were significantly higher in patients with STEMI compared to those with NSTEMI （80.12ng/ml VS.73.01ng/ml, P 〈0.01）, while CRP levels were not significantly different between patient with STEMI and NSTEMI （3.87 ± 0.79 mg/ml VS.4.01 ±0.69mg/ml, P〉0.05）. PAI-1 levels presented a significant correlation with CRP levels in the NSTEMI subjects. However, PAI-1 and CRP levels could explain the lack of a significant relationship between them in control and STEMI subjects.The frequencies of 4G/4G genotype in the AMI group were higher than those in the control group and higher in patient with STEMI than in patient with NSTEMI. Plasma levels of PAI-1 in subjects with 4G/4G genotype were significantly increased as compared to those in subjects with 4G/5G and 5G/5G genotype. Conclusions Plasma PAI-1 levels were associated with different myocardial infarction type, and PAI-1 promoter 4G/5G polymorphisms and CRP may be related to plasma PAI-1 levels