环孢素A治疗儿童难治性肾病综合征26例疗效分析

Clinical effect of cyclosporine A on 26 children in refractory nephrotic syndrome

目的探讨环孢素A治疗儿童难治性肾病综合征的临床疗效。方法 26例难治性肾病综合征患儿入院后口服环孢素A,剂量为2～4mg(/kg·d),同时联合激素治疗,疗程3个月。治疗前及治疗后检测24h尿蛋白定量、血浆白蛋白、血浆胆固醇、尿素氮、血肌酐等指标。结果 26例患儿经治疗后,完全缓解14例,占53.85%;部分缓解10例,占38.46%;未缓解2例,占7.69%。结论环孢素A联合激素能有效治疗难治性肾病综合征。

Objective To explore the clinical curative effect of cyclosporine A to treat children in refractory nephrotic syndrome.Methods The 26 refractory nephrotic syndrome children were treated with CsA,2～4 mg/（kg·d）,Po,and combination with hormone therapy.The course of treatment was 3 months.The 24 h quantitative urinary proteins,plasma albumin,plasma cholesterol,urea nitrogen,plasma creatinine were detected before and after treatment.Results 14 patients（53.84%）were complete,10 patients（38.46%） were part remission,2 cases（7.69%）were non-remission.Conclusion Cyclosporine A combination with hormone to treat children refractory nephrotic syndrome has a significant curative effect.