丙氨酰-谷氨酰胺双肽对急性胰腺炎的治疗分析

Clinical analysis on acute pancreatitis with Ala-Gln

目的评价丙氨酰-谷氨酰胺双肽对急性胰腺炎患者肠道损伤的治疗效果。方法采用随机双盲对照法,将220例受试患者随机分为治疗组和对照组。治疗组静脉滴注丙氨酰-谷氨酰胺双肽,200mL/d。对照组静滴200mL生理盐水,共7d。观察血浆谷氨酰胺浓度、肠黏膜损伤程度、血浆蛋白水平及免疫功能指标。结果治疗组患者血浆谷氨酰胺含量明显高于对照组(P<0.05);肠黏膜损伤程度明显低于对照组(P<0.01);血浆蛋白水平及免疫功能指标明显高于对照组。结论丙氨酰-谷氨酰胺双肽经静脉输入后能显著提高血浆谷氨酰胺浓度,明显减轻急性胰腺炎患者肠黏膜损伤程度,维护肠黏膜屏障功能,增强机体免疫功能,减少机体氮的丢失,提高治疗效果。

Objective To evaluate the clinical therapeutic result of Ala-Gln on intestinal damage of acute pancreatitis patients.Methods Two hundred and twenty patients were randomly divided into treatment group and control group.Treatment group was given Ala-Gln in a dose of 200 mL per day for 7days and control group was given equal amount of NS.The plasma GLN concentration,the severity of intestinal mucosa damage,the level of plasma protein and parameters of immunological function were observed.Results The plasma GLN concentration,the severity of intestinal mucosa damage were slighter in treatment group than those in control group.The level of plasma protein and parameters of immunological function were higher in treatment group than those in control group.Conclusion Administration of Ala-Gln can raise the plasma GLN level,abate the severity of intestinal mucosa damage obviously,maintain the barrier function of intestinal mucosa,enhance the immunological function,reduce the losing of nitrogen and improve the effect of treatment.