预防性使用欣母沛在剖宫产术中的效果观察

Effect of Preventive Use of Hemabate in Caesarean Section

目的:观察在有产后出血高危因素的剖宫产术中预防性使用欣母沛减少产后出血的效果。方法:选择羊水过多、双胎妊娠、巨大胎儿、前置胎盘等有产后出血倾向的孕妇115例,分为观察组58例和对照组57例。观察组在胎儿娩出后常规静滴催产素20 U的基础上,同时子宫体注射欣母沛250μg。对照组在胎儿娩出后只常规静滴催产素20 U。比较2组产后2 h、24 h内的出血量及产后出血发生率。结果:观察组产后2 h、24 h的出血量及产后出血发生率明显低于对照组(P<0.05)。同时观察组产妇恶心、呕吐、胸闷和颜面潮红等副作用的发生率显著高于对照组(P<0.01)。结论:在有产后出血高危因素的剖宫产术中预防性使用欣母沛能减少产后出血,但使用时要注意其不良反应的发生。

Objective：To investigate the effect of Hemabate used preventively in patients with risk factors of postpartum hemorrhage on caesarean section.Methods：115 cases with postpartum bleeding tendency including polyhydramnios,twin pregnancy,fetal macrosomia,placenta previa,were divided into observation group（n=58） and control group（n=57）.In observation group,20 U oxytocin was intravenous infusion onventionally and 250μg Hemabate was Intramuscular in uterus after the baby was delivered;while 20 U oxytocin was intravenous infusion conventionally in control group.The amount of bleeding 2 h,24 h postpartum and the incidence of postpartum hemorrhage were compared in two groups.Results：The amount of bleeding 2 h,24 h postpartum and the incidence of postpartum hemorrhage in observation group were significantly lower than that in control group（P0.05）.But the incidence of side effects in observation group was significantly higher than that in control group（P0.01）,such as nausea,vomiting,chest tightness and facial flushing and so on.Conclusion：Preventively using Hemabate in those who have risk factors of postpartum hemorrhage on caesarean section can reduce postpartum hemorrhage.Hemabate is Worthy in clinical application,but the side effects must be payed attention to.