咳嗽变异型哮喘的临床及肺功能特征

Lung Function and Clinical Characteristics of the Cough Variant Asthma

目的：探讨咳嗽变异型哮喘（cough variant asthm a,CVA）的临床及肺功能特征。方法：分别对32例CVA患者、28例典型哮喘患者和30例健康青年人进行支气管激发试验前后的肺功能（FVC、FEV1、PEF、FEF25%~75%）测定,并比较各组间的差异。结果：CVA组与健康对照组激发试验前肺功能指标比较无显著性差异（P〉0.05）;两组分别与典型哮喘组比较,均有显著性差异（P〈0.05）。健康对照组激发试验前后比较无显著性差异（P〉0.05）;CVA组激发试验前后FEV1、FVC变化不大（P〉0.05）,而PEF、FEF25%~75%变化明显（P〈0.05）。结论：咳嗽变异型哮喘患者激发试验前肺功能在正常范围,激发试验后存在大气道和小气道功能障碍,其肺功能损害在正常与典型哮喘之间。

Objective：To investigate lung function and clinical characteristics of the cough variant asthma（cough variant asthma,CVA）.Methods：32 patients with CVA,included 25 males and 7 females,aged 20-45 years;another 30 cases of healthy young people selected as a control group were 22 males and 8 females,aged 22-43 years;and 28 patients with typical asthma,23 males and 5 females,age 23-43 years old;before and after bronchial provocation had test of pulmonary function（FVC,FEV1,PEF,FEF25%～75%） respectively,and differences among the groups were compared.Results：CVA compared with control groups in the markers of lung function before bronchial provocation,the difference was not statistically significant（P0.05）;the two groups compared with typical asthma,the difference was significant（P0.05）;the control group before and after the provocation test,the difference was not statistically significant（P0.05）;CVA group before and after the provocative test,FEV1,FVC had little changes（P0.05）,and PEF,FEF25%～75% changes significantly（P0.05）.Conclusion：Patients with cough variant asthma have pulmonary function in the normal range before provocation test,but the large airway and small airway are dysfunction after provocation test,their pulmonary function are between the normal people and typical asthma.