安博维对轻、中度原发性高血压病患者左心室舒张功能影响

Effect of Irbesartan on the Left Ventricular Diastolic Function in Patients with Mild and Moderate Essential Hypertension

目的探讨厄贝沙坦(安博维)治疗轻、中度原发性高血压病(EH)患者左心室舒张功能的疗效。方法将89例轻、中度EH患者随机分为厄贝沙坦组和贝那普利组,于用药前和服药6个月后,分别检测24 h动态血压,心脏多普勒超声、血浆脑钠素(BNP)。结果治疗6个月后,各项血压指标较治疗前有显著下降,差异均有统计学意义(P<0.05);两组心脏超声各项指标较治疗前均有改善,且LVPWD、IVSD和LVMI厄贝沙坦组显著低于贝那普利组(P<0.05);两组患者治疗后血浆BNP水平较治疗前均有下降,而厄贝沙坦组下降得更显著,两组比较差异有统计学意义(P<0.05)。结论安博维能够有效降低血压,改善轻、中度EH患者左心室舒张功能。

Objective To study the effect of Irbesartan on the treatment of the left ventricular diastolic function in patients with mild and medium degree essential hypertension. Methods Eighty-nine patients with mild and medium degree essential hypertension were randomly divided into Irbesartan group and Benazepril group and 24h average blood pressure, doppler echocardiography, the lever of brain natriuretic peptide were measured before receiving therapy and after treatment for 6 months. Results Blood pressure and indicators of doppler echoeardiography were all significantly improved in both groups after treatment （ P 〈 0.05 ）, and the levels of LYPWD, IYSD and LVMI decreased more apparently in Benazepril group （ P 〈 0.05 ）. The levels of BNP were significant decreased in both groups after treatment, but more apparently in Irbesartan group （P 〈 0.05 ）. Conclusion Irbesartan can reduce blood pressure and improve the left ventricular diastolic function in patients with mild and medium＇degree essential hypertension.