欣母沛注射液联合缩宫素预防剖宫产产后出血的临床研究

Clinical Study of Postpartum Hemorrhage Prevented by Carboprost Tromethamine Injection and Oxytocin

目的观察联合使用欣母沛注射液和缩宫素对预防孕产妇剖宫产产后出血的临床效果。方法对照组患者单纯注射缩宫素,研究组患者联合注射缩宫素和欣母沛注射液,分别对两组患者术中出血量、产后2h和24h的出血量及不良反应观察记录。结果研究组患者产后出血比例1.25%明显低于对照组5.00%,且研究组患者术中、术后2h、24h平均总出血量[(117.32±76.28)mL,(188.57±60.36)mL,(266.74±73.68)mL]均明显低于对照组[(162.34±53.17)mL,(253.96±81.49)mL,(331.92±86.79)mL],数据经统计学比较差异具有统计学意义(P<0.05);研究组患者临床不良反应率5%明显低于对照组10%,数据经统计学比较差异具有统计学意义(P<0.05)。结论采用欣母沛注射液联合缩宫素预防和治疗剖宫产产后出血具有较好的临床疗效,能够有效减少患者出血量,且不良反应较少。

Objective To observe the clinical effects of carboprost tromethamine injection and oxytocin preventing postpartum hemorrhage of cesarean section. Methods Patients in control group were treated only with oxytocin, and patients in study group were treated combined earboprost trometbamlne with oxytocln. Separately recording the blood loss in, 2h and 24h after operation and observing the adverse reactions of two groups. Results The blood rate of study group 1.25% was significantly lower than control group 5%, and the total blood loss of study group [ （ 117.32 ±76.28 ）mL, （ 188.57 ±60.36 ）mL, （266.74 ± 73.68 ）roLl were significantly lower than control group [（ 162.34 ± 53.17 ） mL, （ 253.96 ± 81.49 ）mL, （ 331.92 ± 86.79 ） mL] in, 2h and 24h after operation （ P 〈 0.05 ）. The adverse reactions rate of study group 5% was significantly lower than control group 10% （ P 〈 0.05 ）. Conclusion It had good clinical effects of carboprost tromethamine injection and oxytocin preventing postpartum hemorrhage of cesarean section. And it could effectively reduce the blood loss and adverse reactions with patients.