2型糖尿病患者代谢综合征组分与血管并发症相关性研究

Relationship of the metabolic syndrome(MS) and its components with diabetic vascular complications in type 2 diabetic patients

目的探讨2型糖尿病(T2DM)患者代谢综合征(MS)组分与糖尿病血管并发症的关联。方法 412例T2DM住院患者,按是否合并MS分为MS组和T2DM组,比较两组间糖尿病血管并发症相关指标的差异及其与MS组分的关联。结果 MS组心血管疾病(CVD)和糖尿病肾病(DN)的发病率明显高于T2DM组。多元逐步回归显示,HDL-C是颈动脉内中膜厚度的独立影响因素;平均动脉压、HDL-C和MS组分数是尿白蛋白排泄率的独立影响因素。结论 T2DM患者MS及其组分与CVD和DN相关。

Objective To investigate the relationship of metabolic syndrome （MS） and its components with diabetic vascular complications in type 2 diabetic patients. Methods The 412 type 2 diabetic patients were divided into two groups with （n=213） and without （n= 199）MS. The prevalence of diabetic vascular complications was compared between two groups. The correlations of the components of the metabolic syndrome with the level of urinary albumin excretion rate （UAER） and carotid artery intimamedia thickness （IMT） were analyzed. Results （1） The prevalence of cardiovascular disease（8. 1% vs 25.4%,P〈0.01） and diabetic nephropathy （44.2% vs 63.8%, P〈0. 01） was significantly higher in patients with MS than those without MS. （2） Multiple regression analysis demonstrated that HDL-C was an independent determinant of IMT（β=-0.01, P〈0. 05）; and MAP, HDL-C and the number of MS components were independent determinants of UAER（β=0.12, P〈0. 05; β=-0. 16, P〈0.01; β=0. 15, P=0. 05）. Conclusion MS and its components are associated with cardiovascular disease and diabetic nephropathy in type 2 diabetic patients.