醒脑灵颗粒渗漉提取工艺

Percolation Extraction Process of Xingnaoling Granules

目的:优选醒脑灵颗粒的最佳渗漉提取工艺。方法:采用单因素试验法,以丹参酮ⅡA提取率、大黄总蒽醌提取率和得膏率为考察指标,对影响醒脑灵颗粒渗漉提取工艺的因素进行研究。结果:最佳渗漉工艺为药材粗粉碎,用2倍量70%乙醇浸泡24 h,以3.0 mL.min-1.kg-1速度渗漉,收集6倍量渗漉液。结论:优选的渗漉提取工艺提取效率高,验证试验结果表明该提取工艺重复性好、稳定可行。

Objective：To optimize the conditions for the percolation extraction processes of Xingnaoling granules.Method： The content of total anthraquinones in Rhei Radix et Rhizome and tanshinoneⅡA and the yield of dry ointment were used as indexes to select the optimal extraction processes with single factor test.Result： The optimal percolation extraction conditions are as follows： the medicinal herbs were crushed into coarse grains and soaked by two folds amount of 70% alcohol for 24 hours,collecting 6 folds of percolation fluid at a rate of 3.0 mL·min-1·kg-1.Conclusion： The optimal percolation extraction technology is efficient with high yields,and the results of verification experiment show that the technology is reproducible and stable.