冠心病患者高迁移率族蛋白B1水平变化的临床研究

The Expression and Significance of HMGB1 in Patients with Coronary Heart Disease

目的:探讨冠心病(CHD)患者血清高迁移率族蛋白B1(HMGB1)水平变化及其临床意义。方法:CHD患者158例,分为急性冠脉综合征组(ACS组,87例)和稳定型心绞痛组(SA组,71例),选择30例年龄和性别匹配的健康体检者作为对照组,采用ELISA检测各组人群血清HMGB1水平,并同时检测超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)和血脂水平。结果:CHD患者血清HMGB1和hs-CRP水平较对照组明显增高(6.47±1.39ng/ml vs 2.19±0.43ng/ml,P<0.01;3.42±0.87g/ml vs 1.15±0.22g/ml,P<0.01)。ACS组患者血清HMGB1水平显著高于SA组(8.52±2.08ng/ml vs 5.38±1.26ng/ml,P<0.01)。ACS组患者血清hs-CRP水平较SA组和对照组也明显升高。CHD患者血清HMGB1水平与hs-CRP水平呈显著正相关(r=0.685,P<0.01)。结论:血清HMGB1水平的变化在CHD的发病过程中有重要意义,可作为CHD的监测指标之一。

Objective: To investigate the relationship between serum high mobility group box 1 protein(HMGB1) level and coronary heart disease(CHD).Method: A total of 158 CHD patients were enrolled in this study,which include 87 patients with acute coronary syndrome(ACS group) and 71 patients with stable angina(SA group).Thirty age-and sex-matched people without CHD were considered as control group.Serum HMGB1 concentration in CHD patients and healthy people was measured by ELISA.The levels of hs-CRP,WBC and blood lipid were detected.Results: HMGB1 and hs-CRP level in CHD group(6.47±1.39ng/ml,3.42±0.87g/ml) was higher than that in control group(2.19±0.43ng/ml,1.15±0.22g/ml)(all P<0.01).HMGB1 level in ACS group(8.52±2.08ng/ml)was higher than that in SA group(5.38±1.26ng/ml)(P<0.01).There was significantly positive correlation between HMGB1 level and hs-CRP level in CHD patients(r=0.685,P<0.05).Conclusion: The present study showed that increased serum HMGB1 may involve in the pathogenesis of CHD,which can be used for monitoring clinical state of CHD.