苏皖地区汉族人群IL-6-572C>G多态性与前列腺癌易感性的关系

Association of IL-6-572C>G polymorphism with the susceptibility to prostate cancer in the Chinese Han population in Jiangsu and Anhui area

目的:研究中国苏皖地区汉族人群IL-6-572C>G多态性与前列腺癌易感性的关系。方法:采用病例-对照研究,提取200例前列腺癌患者(病例组)和279例健康体检的非肿瘤患者(对照组)外周血基因组DNA,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析两组IL-6-572C>G位点的多态性,比较不同基因型与前列腺癌易感性的关系。结果:以携带CC基因型的对象为参照组,携带GG基因型者患前列腺癌的风险提高146%(OR=2.46,95%C I:1.41～4.29)。而携带GG基因型者患前列腺癌的风险是携带GC/CC基因型的2.47倍(95%C I:1.47～4.17)。在高龄(>70岁)、高体重指数(>23 kg/m2)、非吸烟、饮酒和有肿瘤家族史5组人群中,携带GG基因型的个体发病风险显著升高,调整后的OR(95%C I)分别为3.06(1.44～6.49)、3.72(1.79～7.74)、2.96(1.30～6.72)、2.73(1.28～5.79)、6.67(1.50～29.69)。结论:IL-6-572C>G与苏皖地区汉族人群前列腺癌的易感性有关,GG基因型可能是前列腺癌的易感基因型。

Objective： To investigate the association of the IL-6 -572C 〉 G polymorphism with the risk of prostate cancer （PCa） in the Chinese Han population in Jiangsu and Anhui area. Methods： We obtained peripheral blood genome DNA from 200 PCa patients and 279 age-matched PCa-free healthy controls, analyzed the site polymorphism of IL-6 -572C 〉 G with the polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique, and studied the correlation of different genotypes with the susceptibility to PCa. Results ： The subjects that carried the GG genotype had a risk of PCa 2.46 times that of the CC genotype carriers （95% CI = 1.41 -4.29）, and 2.47 times that of the CC/GC genotype carriers （95% CI = 1.47 -4.17 ）. This risk was significantly increased among the following subgroups of GG genotype carriers ： age 〉 70 yr （ OR = 3.06, 95% CI ： 1.44 - 6.49 ）, BMI 〉 23 kg/m2（OR = 3.72, 95% CI： 1.79-7.74）, no cigarette smoking （OR = 2.96, 95% CI： 1.30-6.72）, alcohol drinking （OR = 2.73, 95% CI： 1.28 -5.79）, with a family history of cancer （OR = 6.67, 95% CI： 1150-29.69）. Conclusion： In the Chinese Han population in Jiangsu and Anhui area, IL-6 -572C 〉 G polymorphism is associated with the susceptibility to PCa, and GG might be a susceptible genotype to PCa.