内皮损伤与勃起功能障碍研究进展

Endothelial injury and erectile dysfunction

内皮在维护血管稳态、调节血管紧张度及血流、预防血管内血栓形成等方面起重要作用。血管内皮是阴茎勃起过程中的重要角色,ED多数情况下存在不同程度的内皮功能障碍,内皮损伤是ED的重要病理基础。不良生活方式、心血管疾病、氧自由基、炎症因子等均可导致内皮损伤。血管内皮具有自我修复机制,内皮损伤是损伤因素与修复因素失衡的结果。本文就内皮损伤机制、内皮损伤后的修复、内皮损伤与ED关系等方面的进展作一综述。

The endothelium plays an important role in maintaining vascular homeostasis, regulating vascular tone and blood flow, and preserving a non-thrombogenic blood-tissue interface, and the normal function of the vascular endothelium is essential for penile erection. In most cases, erectile dysfunction （ED） is accompanied by endothelial dysfunction, and endothelial injury is a major pathological basis of ED, which can be induced by bad lifestyles, cardiovascular diseases, reactive oxygen species, and inflammatory mediators. The vascular endothelium is capable of self-repairing, and endothelial injury results from the unbalanced factors of injury and repair. This review focuses on the mechanism and repair of endothelial injury and the relationship of endothelial injury with ED.