青春期多囊卵巢综合征患者瘦素的监测及意义

Clinical significance of monitoring leptin level in adolescent patients with polycystic ovary syndrome

目的通过监测青春期多囊卵巢综合征患者（PCOS）瘦素的含量，探讨瘦素与PCOS的关系，寻求青春期PCOS的分型诊断方法及肥胖型患者的疗效监测指标。方法收集30名正常青春期志愿者（正常对照组）、30例单纯型青春期肥胖者（单纯肥胖组）和41例青春期PCOS患者（27名肥胖者和14名非肥胖者）的空腹血清标本，测定瘦素，并进行统计学分析。结果正常对照组、单纯肥胖组、青春期PCOS肥胖组与PCOS非肥胖组瘦素分别为（19．44±6．63）、（23．09±7．39）、（42．99±9．83）、（31．92±7．02）μg/L，青春期PCOS肥胖组血清中的瘦素高于对照组和单纯肥胖组，且差异均有统计学意义（t值分别为2．903、2．714，P均〈0．05）；青春期PCOS肥胖组瘦素高于青春期PCOS非肥胖组，差异有统计学意义（t=2．472，P〈0．05）。结论测定瘦素可以帮助进一步明确青春期PCOS的分型，有效指导治疗，并可以作为青春期PCOS肥胖患者治疗效果的一个监测指标。

Objective To discuss the relationship between leptin level and polycystic ovary syndrome （PCOS） in adolescent patients with polycystic ovary syndrome, and to explore the classification diagnosis method of adolescent PCOS and indicator for clinical monitoring of obese patients. Methods All enrolled adolescent individuals were assigned into four groups：30 normal adolescent individuals in the control group, 30 simple adolescent obese individuals in the simple obesity group ,27 obese adolescent PCOS patients in the obese PCOS group and 14 nonobese adolescent PCOS patients in the nonobese PCOS group. The fasting serum samples were prepared for lepfin level measurement and analysis. Results The serum leptin level of in the control group, the simple obesity group, the obese PCOS group and the nonobese PCOS group were （ 19.44 ±6. 63 ） μg/L vs. （23.09 ±7. 39） μg/L, （42. 99 ±9. 83） μg/L and （31.92 ±7. 02） μg/L,respectively. Leptin in the obese PCOS group was significantly higher than that in the control group and the simple obese group （ t = 2. 903 and 2. 714 respectively,Ps 〈 0. 05 ）. Conclusion Monitoring the serum level of leptin can not only aid the classification of adolescent PCOS patients and guide the treatment, but also can serve as a indicator for therapeutic monitoring of obese adolescent PCOS.