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痛觉过敏的研究进展 被引量：3

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摘要 外周组织炎症或神经损伤常常引起持续性自发痛（spontaneouspain）、痛觉过敏（hyperalgesia）和痛觉超敏（allodynia）等病理性疼痛。持续性自发痛是指在不受任何外来刺激下持续发生的疼痛，痛觉超敏是指非伤害性刺激即可引起的疼痛，
作者 吕兴业
机构地区 承德护理职业学院生理教研室
出处 《河北医药》 CAS 2011年第15期2344-2347,共4页 Hebei Medical Journal
关键词 过敏 疼痛
分类号 R441.1 [医药卫生—诊断学]
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参考文献16

  • 1Guan Y ,Terayama R, Dubner R ,et al, Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation. Pharmacol Exp Ther,2002 ,300 :513-520.
  • 2Fujita T, Kamisaki Y, Yonehara N. Nitric oxide-induced increase of excitatoryamino acid levels in the trigeminal nucleus caudahs of the rat with tactilehypersensitivity evoked by the loose-ligation of the inferior alveolar nerves. Neurochem,2004,91:558-567.
  • 3Schmidt AP, Tort AB, Silveira PP, et al. The NMDA antagonistMK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats : reversal by guanosine. Pharmacol Biochem Behav,2009,91:549-553.
  • 4Yan LH, Hou JF, Liu MG, et al. Imbalance between excitatory and inhibitory amino acids at spinal level isassociated with maintenance of persistent pain-related behaviors. Pharmacol Res,2009,59:290-299.
  • 5Wong CS, Wu GJ, Chen WF, et al. N-Methyl-D-aspartate receptor antagonist d-AP5 prevents pertussis toxin-inducedalterations in rat spinal cords by inhibiting increase in concentrations ofspinal CSF excitatory amino acids and downregulation of glutamate transporters. Brain Res Bull,2009, 80:69 -74.
  • 6Wu GJ,Wen ZH, Chang YC, et al. Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release andreduction of the antinociceptive effect of morphine in rats injectedintrathecally with pertussis toxin. Life Sci,2006,78:1801-1807.
  • 7Oe K, Narita M, Imai S, et al. Inhibition of the morphine-induced reward- ing effect by direct activation of spinal protein kinase C in mice. Psychopharmacology (Berl) ,2004,177:55-60.
  • 8Sweitzer SM, Wong SM, Tjolsen A, et al. Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain ,2004,110:281-289.
  • 9Lee JS, no JY. Peripheral metabotropic glutamate receptor 5 mediatesmechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. Neumscience,2007,146:375-383.
  • 10Chiu HY, Lin HH, Lai CC. Potentiation of spinal NMDA-mediated nociception by cocaine- and amphetamine-regnlated transcript peptide via PKA and PKC signaling pathways in rats. Regnl Pept, 2009,158 : 77- 85.

同被引文献60

  • 1邱宇洁,梁宜,方剑乔,房军帆,杜俊英,刘晋.慢性疼痛的JNK信号转导通路机制的研究进展[J].浙江中医药大学学报,2011,35(5):793-796. 被引量：5
  • 2张力军,杨雪琴,吕沙里,李铀.腹式呼吸训练仪对心率及呼吸性窦性心律不齐作用的初步观察[J].北京生物医学工程,2005,24(1):39-41. 被引量：31
  • 3Lee M, Silverman SM, Hansen H, et al. A comprehensive review of opioid-induced hyperalgesia[J]. Pain Physician, 2011, 14(2): 145-161.
  • 4Colvin LA, FaUon MT. Opioid--induced hyperalgesia: a clinical challenge[J].BrJ Anaesth, 2010, 104(2): 125-127.
  • 5Dietis N, Guerrini R, Calo G, et al. Simultaneous targeting of multi- ple opioid receptors: a strategy to improve side-effect profile[J]. Br J Anaesth, 2009, 103(1): 38-49.
  • 6Haugan F, Rygh LJ, Tj#lsen A. Ketamine blocks enhancement of spinal long--term potentiation in chronic opioid treated rats[J]. Acta Anaesthesiol Scand, 2008, 52(5): 681-687.
  • 7Zhao M, Joo DT. Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptorsas a mechanism for acute opioid-induced hyperalgesia or tolerance [J]. Anesthesiology, 2008, 109(2): 308-317.
  • 8Van Elstraete AC, Sitbon P, Mazoit JX, et al. Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats [J]. Anesthesiology, 2008, 108(3): 484-494.
  • 9Minville V, Fourcade O, GirolamiJP, et al. Opioid-induced hyper- algesia in a mice model of orthopaedic pain: preventive effect of ket- amine [J]. BrJ Anaesth, 2010, 104(2): 231-238.
  • 10Schmidt AP, Tort AB, Silveira PP, et al. The NMDA antagonist MK--801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine[J]. Pharmacol Biochem Behav, 2009, 91 (4): 549-553.

引证文献3

二级引证文献5

河北医药
2011年 第15期

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