期刊文献+

舒芬太尼对心脏瓣膜置换术患者围术期血清cTnI水平的影响及意义 被引量:2

下载PDF
导出
摘要 目的探讨舒芬太尼对心脏瓣膜置换术患者的心肌保护作用及机制。方法将22例择期行瓣膜置换术患者随机分为观察组和对照组各11例,两组均持续泵入丙泊酚行麻醉维持,麻醉诱导、锯胸骨时、体外循环转流时、停机时观察组静注舒芬太尼0.5~1μg/kg,对照组静注芬太尼5~10μg/kg。观察两组开胸时(T1)、主动脉开放30 min(T2)、术毕(T3)及CPB停机4 h(T4)、24 h(T5)血清超敏心肌肌钙蛋白I(cTnI)水平。结果两组T2~T5时点cTnI水平均明显高于T1,观察组T4、T5时点cTnI水平明显低于对照组,P均<0.05。结论舒芬太尼对心脏瓣膜置换术患者的心肌保护作用优于芬太尼。
出处 《山东医药》 CAS 北大核心 2011年第27期64-65,共2页 Shandong Medical Journal
基金 海南省卫生厅科研立项课题项目(琼卫2009-75)
  • 相关文献

参考文献4

二级参考文献17

  • 1林霖,王伟鹏,张燕婉,刘进.两种剂量芬太尼对冠状动脉旁路移植术患者血液动力学及血浆儿茶酚胺的影响[J].中华麻醉学杂志,2004,24(6):460-461. 被引量:23
  • 2钟白,齐娟.心脏瓣膜置换术患者等效剂量舒芬太尼或芬太尼复合麻醉的效果[J].中华麻醉学杂志,2006,26(12):1117-1117. 被引量:1
  • 3Patel HH, Fryer RM, Gross ER, et al. 12-lipoxygenase in opioidinduced delayed eardioproteetion: gene array, mass spectrometric, and pharmacological analyses. Circ Res, 2003, 92:676-682.
  • 4Jiang XJ, Shi E, Nakajima Y, et al. COX-2 mediates morphine-induced delayed eardioproteetion via an iNOS-dependent meehanism. Life Sci, 2006, 78 : 2543-2549.
  • 5Ludwig LM, Patel HH, Gross GJ, et al. Morphine enhances pharma- cological preconditioning by isoflurane: role of mitochondrial KATe channels and opioid receptors. Anesthesiology, 2003, 98: 705-711.
  • 6Hudson RJ, Henderson BT, Thomson tR, et al. Pharmaeokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vase Anesth, 2001, 15: 693-699.
  • 7Frassdorf J, Weber NC, Obal D, et al. Morphine induces late cardioprotection in rat hearts in vivo : the involvement of opioid receptors and nuclear transcription factor-riB. Anesth Analg, 2005, 101 : 934-941.
  • 8Guo Y, Stein AB, Wu WJ, et al. Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and deltal-opioid receptor agonists is mediated by iNOS. Am J Physiol Heart Cire Physiol, 2005, 289: H2251-H2257.
  • 9Chen M, Zhou JJ, Kam KW, et al. Roles of KATV channels in delayed cardioprotection and intracellular Ca^2+ in the rat heart as revealed by κ- opioid receptor stimulation with U50488H. Br J Pharmacol, 2003, 140: 750-758.
  • 10Zhang Y, Irwin MG, Wong TM. Remifentanil preconditioning protects against ischemic injury in the intact rat heart. Anesthesiology, 2004, 101 : 918-923.

共引文献65

同被引文献43

引证文献2

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部