冠心病患者血浆基质细胞衍生因子-1α水平变化分析

Analysis of the change of serum stromal cell-derived factor-1α in patients with coronary heart disease

目的：探讨冠心病患者血浆基质细胞衍生因子-1α（SDF-1α）的水平变化及与冠状动脉病变程度之间的关系。方法：应用ELISA检测32例急性心肌梗死（AMI）组、18例不稳定型心绞痛（UAP）组、20例稳定型心绞痛（SAP）组患者和23名正常对照组的血浆SDF-1α水平。心绞痛患者、正常对照组和部分AMI患者行冠状动脉造影术,根据冠状动脉狭窄程度进行分组：轻度组11例,中度组15例,重度组20例,与23名对照组进行血浆SDF-1α水平比较。结果：对照组、SAP组、UAP组、AMI组血浆SDF-1α水平依次降低,除对照组和SAP组差异无统计学意义外,其余各组间差异均有统计学意义（P〈0.01）。中、重度冠状动脉狭窄组血浆SDF-1α水平低于对照组和轻度组（P〈0.05~P〈0.01）。结论：血浆SDF-1α水平在冠心病患者低表达,并与冠心病严重程度及冠状动脉狭窄程度有关。

Objective：To evaluate the changes of serum stromal cell-derived factor-1α（SDF-1α） levels in coronary heart disease,and the correlation between SDF-1α and severity of coronary lesions.Methods：By ELISA,the levels of SDF-1α from 32 patients with acute myocardial infarction（AMI）,18 patients with unstable angina pectoris（UAP）,20 patients with stable angina pectoris（SAP） and 23 subjects without coronary heart disease（CHD） as control were measured.The patients with angina pectoris,control group and some patients with AMI were underwent coronary angioplasty（CAG）.The patients who performed CAG with CHD were divided into three groups according to the severity of coronary artery stenosis：minor group（n=11）;moderate group（n=15） and severe group（n=20）.The levels of serum SDF-1α were compared with 23 controls.Results：The levels of Serum SDF-1α in control group,SAP group,UAP group,AMI group were successively decreased,and the levels of SDF-1α were lower in the severe and moderate groups than those in control and minor groups（P〈0.05-P〈0.01）.Conclusions：Lower levels of SDF-1α were expressed in coronary heart disease,serum levels of SDF-1α were correlated with the severity of coronary artery disease and the stenosis degree of coronary arteries.