布地奈德联合沙丁胺醇雾化吸入治疗支气管哮喘急性发作的临床观察

The clinical observation of combination chemotherapy of salbutamol and budesonide in aerosol inhalation treatment of acute attack of bronchial asthma

目的:观察布地奈德联合沙丁胺醇雾化吸入治疗支气管哮喘急性发作的临床疗效。方法:将63例急性发作期支气管哮喘患者随机分为2组,其中对照组30例单用沙丁胺醇雾化吸入,治疗组33例在对照组的基础上加用布地奈德。比较2组患者的总体疗效、主要症状、体征持续时间及肺功能变化情况。结果:对照组总有效率为86.67%,治疗组总有效率93.94%,差异无统计学意义(P>0.05)。治疗组的胸闷、气短、咳嗽、肺哮鸣音等症状、体征消失时间均较对照组明显缩短;2组患者治疗后第一秒用力呼气容积、用力肺活量、呼气峰流速均显著升高(P<0.01),且治疗组肺功能改善较对照组更明显(P<0.01)。结论:布地奈德联合沙丁胺醇雾化吸入治疗支气管哮喘,可明显改善症状,增强肺功能,值得临床推广应用。

Objective：To observe the clinical efficacy of inhalation treatment with salbutamol and budesonide combination for acute attack of bronchial asthma.Methods：Sixty-three cases of acute attack of bronchial asthma were randomly divided into two groups,30 patients in control group with salbutamol inhalation,33 patients in treatment group treated with salbutamol combined with budesonide.The overall efficacy,main symptoms,sign duration time and the changes of lung function in the two groups were compared.Results：The total effective rate was 86.67% and 93.94% in control group and treatment group,respectively,there was no statistical difference in the two groups（P〉0.05）.In treatment group,chest tightness,shortness of breath,coughing,wheezing and other lung symptoms,sign disappeared time were significantly shortened compared with control group.The first second forced expiratory volume,forced vital capacity,peak expiratory flow after treatment were significantly higher than before treatment in the two groups（P〈0.01）,and the lung function in treatment group was improved more significantly than in control group（P〈0.01）.Conclusions：The overall efficacy of budesonide combined with salbutamol inhalation in treatment of asthma is notable,it can remarkably improve symptoms and enhance lung function,which is worthy of clinical application.