聚乙烯表面亲水化改性及其血液相容性改进

Surface modification of PE for improving its hydrophilicity and blood compatibility

以过氧化苯甲酰(BPO)为引发剂,在聚乙烯(PE)膜表面接枝丙烯酸(AA)以改善其亲水性。系统地讨论了引发剂浓度、单体浓度、反应温度以及反应时间等各影响因素对接枝率的影响,并通过傅立叶变换红外(FT-IR)、表面水接触角等物理手段来表征接枝膜的表面结构、亲水性等性能。实验结果表明BPO能成功引发丙烯酸接枝PE膜,接枝改性后PE膜亲水性有了明显的提高。采用了3种比较直观的常规评价方法对PE膜接枝改性前后的血液相容性进行初步的评价。研究结果表明表面接枝AA后的PE膜与血细胞的相互作用较弱,对血细胞的破坏程度明显减小,其抗凝血性比未接枝改性膜有显著提高。

Acrylic acid（AA） was grafted onto the surface of polyethene（PE） films to improve their hydrophilicity and anti-clotting properties.The grafting reaction was performed using a benzoyl peroxide（BPO） initiator.Effects of such conditions as BPO concentration,monomer concentration,the optimum temperature and polymerization time on degree of grafting was systemically investigated.The structure and hydrophilicity of ungrafted films and grafted films have been characterized by FT-IR and surface water contact angle test respectively.The results showed that acrylic acid was successfully grafted onto the surface of PE films by BPO,the hydrophilicity of grafted PE films were improved significantly.Three commonly used intuitionistic methods were employed to evaluate the blood compatibility of ungrafted films and grafted films.The results showed that PE-g-AA films have very slight interaction with blood cells.The grafted films can remarkably postpone the activation of coagulation factors and intrinsic coagulation system,and can effectively resist the intrinsic coagulation route,it means anti-clotting properties of grafted films were much improved than that of the ungrafted films.