摘要
在盐酸底液中，单硝酸异山梨酯（简称ＩＳＭＮ）在汞电极上于－ ０．５０Ｖ和－０．８８Ｖ（ｖｓ．ＳＣＥ）可产生两个不可逆的还原峰。用循环伏安法（ＣＶ），微分脉冲极谱（ＤＰＰ），常规脉冲极谱（ＮＰＰ）及恒电位电解等多种电化学方法研究了该本系的电化学行为和电极机理，两个峰的产生是因硝酸酯的两步不可逆还原所致。利用第一个峰单扫描极谱法测定了片剂中单硝酸异山梨酯的含量，线性范围为０．０２～２０ｍ ｇ／Ｌ，检测下限为０．０１ｍｇ／Ｌ，并探讨了影响灵敏度的主要因素。
An electroanalytical method for the determination of Isosorbid 5 mononitrate based on Oscillopolarographic method was developed. The linear relationship held in the range of 0.02～20mg/L, with the detection limit of 0.01mg/L. The electrochemical behaviour and the mechanisms of electrode reaction were studied by means of linear sweep voltammetry and pulse polarography, etc. and the wave was confirmed to be of irriversible.
出处
《实验室研究与探索》
CAS
1999年第6期74-76,共3页
Research and Exploration In Laboratory
基金
山东省自然科学基金
关键词
单硝酸异山梨酯
电化学
抗心绞痛药
isosorbid 5-mononitrate
electrochemical behaviour
oscillopolarography
