吖啶-4-甲酰胺衍生物的合成与表征

Synthesis and Characterization of Acridine-4-Formamide Derivatives

吖啶类衍生物作为生物大分子探针具有广阔应用前景。本文以4-羧基吖啶酮为母体,在4位上引入N-(2-二甲氨基)乙基,并进一步在9位引入α-丙氨酸或N-(2-二甲氨基)乙基,合成了3种吖啶-4-甲酰胺衍生物:N-(2-二甲氨基)乙基-9-氯吖啶-4-甲酰胺(NCAF)、9-[(N-2-二甲氨乙基)吖啶-4-甲酰胺]-α-丙氨酸(NAFA)及4,9-二[N-(2-二甲氨基)乙基]-9-吖啶胺-4-甲酰胺(DNAF)。通过质谱、核磁共振谱对产物进行了表征。

Acridine derivatives as biomacromolecule probes had broad application prospects.Using 4-carboxy-acridone as a parent body,N-（2-dimethylamino） ethyl on 4 site was introduced,on this basis,alanine or N-（2-dimethylamino） ethyl on 9 site,N-（2-dimethylamino） ethyl-9-chloro-acridine-4-formamide（NCAF）,9-[（N-2-dimethyl-aminoethyl） acridine-4-formamide]-α-alanine（NAFA） and 4,9-di[N-（2-dimethylamino） ethyl]-9-aminoacridine-4-formamide（DNAF） were introduced.Characterization was carried out on the products through such means as mass spectrum and nuclear magnetic spectrum.