血根碱酊剂体外抗真菌初步研究

Preliminary Investigation in the Antifungal Function of Sanguinarine Tincture

通过分析博落回(Macleaya cordata(willd)R.Br.)提取物——血根碱(制成血根碱酊剂)、总生物碱对须癣毛癣菌(Trichophyton mentagrophytes)、玫瑰色毛癣菌(Trichophyton rosaceum)、许兰黄癣菌(Trichophyton schoenlei-ni)、红色毛癣菌(Trichophyton rubrum)几种皮癣真菌的抑菌试验,以探讨血根碱酊剂和总生物碱对皮癣致病真菌的抑制作用。结果表明:血根碱酊剂对须癣毛癣菌、许兰黄癣菌的最小抑菌浓度为16μg/mL,对玫瑰色毛癣菌的最小抑菌浓度为128μg/mL,对红色毛癣菌的最小抑菌浓度为64μg/mL;在含等量血根碱的条件下,血根碱酊剂的抗皮癣真菌效果比博落回总生物碱好。血根碱酊剂具有良好的抗真菌效果,可用于治疗脚癣。

The inhibitory effects of the sanguinarine tincture and total alkaloids, which were extracted from Macleaya cordata, on several psoriasis fungi including Trichophyton Trichophyton schoenleini and Trichophyton rubrum were preliminarily investigated in sults indicated that the MIC of sanguinarine tincture for , Trichophyton rosaceum, the present work. The reTrichophyton mentagrophytes, Trichophyton schoenleini, and Trichophyton rosaceum, were 16 μg/mL, 128 μg/mL and 64 μg/mL, respectively. With same concentration, effectiveness of sanguinarine tincture was better than that of total alkaloids. Therefore, the sanguinarine demonstrated significant effects on antimycotic, and may be used to treat dermatophyt3sis on foot.