蓝舌病病原分子生物学及免疫学研究进展

Progress on Pathogen Molecular Biology and Immunology of Bluetongue

蓝舌病病毒通过吸血昆虫(库蠓)在易感反刍动物之间叮咬进行传播。在家畜中,蓝舌病易发于某些品种的羊,具有典型症状,呈地方性流行;牛感染蓝舌病通常不表现出临床症状。作者分析和总结了近年蓝舌病疫情发生和传播可能的潜在路线,病毒分子生物学研究概况,致病机理及宿主对蓝舌病病毒的免疫反应,并对蓝舌病疫苗的研究进展作了介绍,建议要加强对该病的深入研究,防患于未然。

Bluetongue virus（BTV） is transmitted from infected to susceptible ruminants by hematophagous vector midges（Culicoides species）.Amongst domestic livestock,bluetongue is most common in certain breeds of sheep.BTV infection of sheep with clinical symptom is typical in enzootic regions.BTV infection of cattle are most common,whereas asymptomatic.This review analysed and summarized the BTV epidemic situation and potential spread of disease transimission line,as well as the progress on the molecular biology and pathogensis of BTV and the host immune response against BTV.Furthermore,the advances on vaccine of BTV were descirbed,and also suggested to enhance the study of BTV for provention BTV in the future.