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EB病毒膜抗原的表达与IL-6和TNF-α水平相关性研究 被引量：1

Research about the Relation between the Expression of Epstein-Barr Virus Membrane Antigen and the Levels of IL-6 and TNF-α
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摘要 本研究旨在探讨EB病毒(Epstein-Barr virus,EBV)膜抗原(membrane antigen,MA)的表达与小鼠血清中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的关系。采用ELISA方法检测EB病毒BLLF1基因转基因小鼠和对照组KM小鼠外周血中IL-6和TNF-α水平,结果显示EB病毒BLLF1基因转基因小鼠血清中IL-6和TNF-α水平均显著或极显著高于KM小鼠,表明EB病毒膜抗原(MA)的表达可促使IL-6和TNF-α的过表达。 To study the relation between the expression of EBV membrane antigen（MA） and the levels of IL-6 and TNF-α.Taking the KM mouse as the control group,ELISA was applied to observe the level of IL-6 and TNF-α in the mouse.The level of IL-6 in the EBV mice increase compared to the KM mice.The level of TNF-α in the EBV mice went up significantly compared to the KM mice.We proved that expression of EBV membrane antigen（MA） could promote expression of IL-6 and TNF-α.
作者 康爱君 郭长占 田枫 郑振辉
机构地区 北京大学医学部实验动物科学部 北京大学医学部基础医学院免疫学系
出处 《中国畜牧兽医》 CAS 北大核心 2011年第8期225-227,共3页 China Animal Husbandry & Veterinary Medicine
基金 国家自然科学基金面上项目(30171043)
关键词 EB病毒膜抗原(MA) BLLF1转基因小鼠 白细胞介素-6 肿瘤坏死因子-Α Epatein-Barr virus membrane antigen（MA） BLLF1 transgenic mouse IL-6 TNF-α
分类号 R392 [医药卫生—免疫学]
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参考文献8

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二级参考文献5

共引文献9

同被引文献39

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中国畜牧兽医
2011年 第8期

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