摘要
目的 探讨一氧化氮(NO)与肝硬化、肝功能分级及肝硬化并发症的关系。方法 应用Griess 比色法检测56 例肝硬化病人及20 例正常人血清NO 代谢产物亚硝酸盐和硝酸盐(NO-2 /NO-3 ) 水平。结果 肝硬化组NO-2 /NO-3 水平为(31-4±24-0)μmol/L,较正常对照组(6-2±1-9)μmol/L 明显升高, P< 0-001 。而且随肝功能Child- Pugh 分级的增加而升高。Child - Pugh A 级与对照组比较,前者较后高,但统计学分析差异无显著性, P>0-05 。B级与A 级、B级与C级比较差异非常显著, P< 0-001。并发原发性腹膜炎、食道胃底静脉曲张破裂出血和肝病性低氧血症组分别为(67-5±15-5) 、(22-7 ±6-5) 、(47-6 ±22-9)μmol/L,比无上述并发症肝硬化组的(12-5±5-2)μmol/L明显升高,P< 0-01 ~0-001 。结论 肝硬化时NO合成增加,并且与肝硬化病情严重程度及并发症的发生密切相关。检测血清NO-2 /NO-3
Objective Toinvestigatethelevelofplasma Nitric Oxide(NO)to assessitsrole onleverfunctioninjury and the complication ofcirrhosisand the possiblerelation between them .Methods NOwere measuredin plasmasamplescol lected from 56livercirrhosispatients with and20 healthycontrolsby NOcolorometricassay.Results Higherplasmalevel of NOwere observedin patients with cirrhosisthanin normalcontrols( P< 0-001) .The higher Child- Pugh ,the higher plasma NOlevel.Plasma NOlevel were higher in patients with primary peritonitis and the hemorrhage of esophageal varicesand hypoxemia than in patients without complication( P < 0-01 ~0-001).Conclusion Theincrease of plasma NOisclosely associated with theseverity oflevercirrhosisandthecomplication oflevercirrhosis
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
1999年第12期741-742,共2页
Chinese Journal of Practical Internal Medicine
关键词
肝硬化
一氧化氮
肝功能
血清诊断
Liver cirrhosis Nitric oxide Liver function Complication