山莨菪碱合用黄体酮治疗肾绞痛疗效观察

Observation of the Efficacy of the Integration of Anisodamine and Progesterone in Treating Renal Colic

目的观察山莨菪碱合用黄体酮治疗肾绞痛的临床疗效。方法将132例肾绞痛患者随机分为2组,试验组68人,对照组64人。试验组应用黄体酮40 mg肌肉注射,山莨菪碱10 mg加入5%葡萄糖250 mL静脉滴注滴完;对照组仅用山莨菪碱15 mg加入5%葡萄糖250 mL静脉滴注滴完。观察用药1 h后的镇痛效果及不良反应。结果试验组显效率为51.47%和总有效率88.23%;对照组显效率25.00%和总有效率53.12%,差异有统计学意义(P<0.01)。对照组不良反应率高于试验组(P<0.01)。结论山莨菪碱加黄体酮较单用山莨菪碱能有效缓解肾绞痛,且不良反应较少。

Objective To observe the clinical efficacy of the integration of anisodamine and progesterone in treating renal colic.Method 132 patients with renal colic were randomly divided into 2 groups,with 68 patients in experimental group and 64 patients in control group.The experimental group received muscle injection of 40 mg progesterone and intravenous drip of 10 mg anisodamine mixed with 5% glucose（250 mL）;the control group just received the intravenous drip of 15 mg anisodamine mixed with 5% glucose（250 mL）.The analgesic effects and adverse reaction after the use of drug for one hour were observed.Results The rate of efficacy of experimental group was 51.47% and its total effective rate was 88.23%;the rate ofefficacy of control group was 25.00% and its total effective rate was 53.12%,the differences were statistically significant（P〈0.01）.The rate of adverse reaction of control group was higher than that of experimental group（P〈0.01）.Conclusion The integration of anisodamine and progesterone is more effective to release renal colic than using anisodamine only,and it has fewer side effects.