桂枝人参汤加味对2型糖尿病胰岛素抵抗患者胰岛素敏感指数的影响

Effect of Guizhi Renshen Decoction on Insulin Resistance in Patients with Insulin Sensitivity Index

目的:观察在健脾法指导下,加味桂枝人参汤对胰岛素抵抗(IR)患者胰岛素敏感指数的影响。方法:将符合诊断标准的IR患者60例,按就诊顺序随机分为治疗组和对照组,每组各30例。在糖尿病教育的基础上,嘱患者遵守糖尿病饮食,并适度运动。治疗组给予加味桂枝人参汤水提剂,对照组给予罗格列酮片4 mg,1次/d,60 d为1疗程,共治疗2疗程。检测并比较患者空腹血糖和血清胰岛素,并计算胰岛素敏感指数。结果:两组治疗后与治疗前比较,空腹血糖、空腹胰岛素、胰岛素敏感指数均有显著差异(P<0.01),治疗后中药治疗组空腹血糖与西药对照组比较无显著性差异(P>0.05),中药治疗组空腹血清胰岛素、胰岛素敏感指数与西药对照组比较有显著性差异(P<0.05)。结论:加味桂枝人参汤可降低胰岛素抵抗患者的临床症状,调节空腹血糖、空腹血清胰岛素,增加胰岛素敏感指数,且效果优于西药罗格列酮。

Objective： To observe the law under the guidance of Jiawei Guizhi Renshen Decoction on insulin resistance in patients with insulin sensitivity index.Methods： 60 cases with the diagnostic criteria of IR patients according to the visiting sequence were randomly divided into treatment group and control group,30 cases in each group.On the basis of diabetes education instructing patients to comply with the diabetes diet and moderate exercise.The treatment group were given Jiawei Guizhi ginseng soup extraction agent,the control group given rosiglitazone tablets 4mg,1 time daily,2 months as a course of treatment,a total of two courses.Detection and comparison of fasting blood glucose and serum insulin and insulin sensitivity index was calculated.Results： Two groups before and after treatment,fasting blood glucose,fasting insulin,insulin sensitivity index had a significant difference（P0.01）,after treatment with Chinese medicine treatment group and the control group of Western medicine compared fasting glucose showed no significant difference（P0.05）,Chinese medicine treatment group and fasting serum insulin,insulin sensitivity index and Western medicine in comparison to the control group,there was significant difference（P0.05）.Conclusion： modified Guizhi ginseng Tang Ke reducing insulin resistance in patients with clinical symptoms,regulation of fasting blood glucose,fasting serum insulin,increased insulin sensitivity index,and the effect is superior to western medicine in rosiglitazone.