摘要
目的:阐明输血传播病毒(TTV)感染在血液透析、慢性肝炎病人中的临床意义及其致病作用。方法:以套式聚合酶链反应(PCR)检测血清TTVDNA。结果:31例血液透析患者10例TTVDNA阳性,其中6例有血清转氨酶(ALT)水平升高(76~243U/L),但均同时伴有HBsAg或/和抗HCV阳性,2例单纯TTVDNA阳性者血清TTVDNA持续阳性至少8个月,而ALT水平一直处在正常水平。TTVDNA阳性率在慢性乙型肝炎、慢性丙型肝炎及慢性非甲~戊型、非庚型肝炎中分别为28.3%(17/60),29.3%(10/41)和31.1%(14/45)。TTVDNA阳性、阴性两组慢性乙、丙型肝炎在年龄、病程及ALT、AST、TBil水平均无显著差异(P>0.05)。14例非甲~戊型、非庚型肝炎患者中13例表现为单项ALT水平轻度升高,临床症状轻微。结论:TTV感染存在慢性携带状态,可能是非甲~成型、非庚型肝炎的重要致病因子,但其致病性可能较弱。
篛bjective: To investigate the clinical significance of TTV infection in patients onhemodialysis and with chronic hepatitis. Methods: A nested polymerase chain reaction (PCR) was estab-lished to detect serum TTV DNA. Results:of 31 cases on hemodialysis, 10 were TTV DNA positive. 6out of 10 TTV DNA positive patients had elevated serum alanine aminotransferase (ALT) levels (76~243U/L) and positive HBsAg and/or anti-HCV. 2 cases had persistent positive TTV DNA for at least 8months,although normal ALT levels were found. The positive rate of TTV DNA was 28.3%(17/6O) inchronic hepatitis B,29.3% (12/41) in chronic hepatitis C, and 31.1% (14/45) in chronic hepatitis non-A^E and G,respectively. No clinical and chemical significant difference was found between TTV DNApositive and negative patients with chronic hepatitis B or C between. Among 14 patients with chronicnon-A^E and positive TTV DNA, 13 had slightly elevated serum ALT and mild clinical symptoms.Conclusions:Patients infected with TTV may exist as permanent healthy carriers. TTV could be an im-portant pathogen of non-A^E and G,although its pathogenic effect might be weak.
出处
《江苏医药》
CAS
CSCD
1999年第12期899-901,共3页
Jiangsu Medical Journal
基金
江苏省卫生厅科研基金!H9710