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β-转化生长因子和结缔组织生长因子与低氧致组织纤维化关系研究进展 被引量：1

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摘要 低氧条件下,人体某些组织和器官可发生纤维化改变,导致其功能受损,甚至丧失,在这个过程中,转化生长因子β(Transforming growth factor-beta,TGF-β)一直被认为是致纤维化关键的细胞因子,它除致纤维化作用外,还有抗炎、抗肿瘤及抑制免疫等生物学效应,但是单纯干扰TGF-β的正面效应限制了抗TGF-β抗体的应用,可能引起许多难以预料的不良反应。而结缔组织生长因子(connective tissuegrowth factor,CTGF)是近年来新发现的TGF-β下游的一个信号介质,主要介导TGF-β的促细胞增生和细胞外基质合成,掌握TGF-β及其CTGF的促纤维化机制及其与低氧的调节关系,为应用TGF及CTGF的抑制剂及其抗体等抗纤维化治疗提供更好的依据。
作者 郑杰 李占全 冀林华
机构地区 青海大学医学院
出处 《现代医药卫生》 2011年第15期2314-2315,共2页 Journal of Modern Medicine & Health
关键词 低氧 转化生长因子-Β 结缔组织生长因子 纤维化
分类号 R36 [医药卫生—病理学]
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参考文献15

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共引文献2

同被引文献18

  • 1唐仕芳,朱洪春,李华强,史源,赵锦宁,胡章雪.外源性抗转化生长因子-β_1抗体对新生大鼠高浓度氧致肺纤维化的影响[J].中国循证儿科杂志,2007,2(2):132-137. 被引量：6
  • 2Son JY,Kim SY, Cho SH,et al. TGF-pi T869C polymorphism mayaffect susceptibility to idiopathic pulmonary fibrosis and disease seve-rity[J]. Lung,2013,191(2) :199 -205.
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  • 4Fan X,Zhang Q, Li S, et al. Attenuation of CC14-Induced hepaticfibrosis in mice by vaccinating against TGF-(31 [ J]. PLoS One,2013,8(12) :e82190.
  • 5Nkyirabeng T, Ruppert C, Shiomi T,et al. Pivotal role of matrixmetalloproteinase 13 in extracellular matrix turnover in idiopathic pul-monary fibrosis[J]. PLoS One,2013 ,8(9) :e73279.
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现代医药卫生
2011年 第15期

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